Amyloid plaques of Alzheimer´s disease as hotspots of glutamatergic activity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F19%3A43920029" target="_blank" >RIV/00023752:_____/19:43920029 - isvavai.cz</a>
Result on the web
<a href="https://journals.sagepub.com/doi/10.1177/1073858418791128" target="_blank" >https://journals.sagepub.com/doi/10.1177/1073858418791128</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/1073858418791128" target="_blank" >10.1177/1073858418791128</a>
Alternative languages
Result language
angličtina
Original language name
Amyloid plaques of Alzheimer´s disease as hotspots of glutamatergic activity
Original language description
Deposition of amyloid plaques in limbic and associative cortices is amongst the most recognized histopathologic hallmarks of Alzheimer’s disease. Despite decades of research, there is a lack of consensus over the impact of plaques on neuronal function, with their role in cognitive decline and memory loss undecided. Evidence has emerged suggesting complex and localized axonal pathology around amyloid plaques, with a significant fraction of swellings and dystrophies becoming enriched with putative synaptic vesicles and presynaptic proteins normally colocalized at hotspots of transmitter release. In the absence of hallmark active zone proteins and postsynaptic receptive elements, the axonal swellings surrounding amyloid plaques have been suggested as sites for ectopic release of glutamate, which under reduced clearance can lead to elevated local excitatory drive. Throughout this review, we consider the emerging data suggestive of amyloid plaques as hotspots of compulsive glutamatergic activity. Evidence for local and long-range effects of nonsynaptic glutamate is discussed in the context of circuit dysfunctions and neurodegenerative changes of Alzheimer’s disease.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuroscientist
ISSN
1073-8584
e-ISSN
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Volume of the periodical
25
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
288-297
UT code for WoS article
000485959800004
EID of the result in the Scopus database
2-s2.0-85052516257