Glutamate carboxypeptidase II does not process amyloid-beta peptide

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10189921" target="_blank" >RIV/00216208:11310/13:10189921 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/13:00424007

Result on the web

<a href="http://dx.doi.org/10.1096/fj.12-225094" target="_blank" >http://dx.doi.org/10.1096/fj.12-225094</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1096/fj.12-225094" target="_blank" >10.1096/fj.12-225094</a>

Result language

angličtina

Original language name

Glutamate carboxypeptidase II does not process amyloid-beta peptide

Original language description

The accumulation of amyloid- (A) peptide is thought to be a major causative mechanism of Alzheimer's disease. A accumulation could be caused by dysregulated processing of amyloid precursor protein, yielding excessive amounts of A, and/or by inefficient proteolytic degradation of the peptide itself. Several proteases have been described as A degradation enzymes, most notably metalloendopeptidases, aspartic endopeptidases, and some exopeptidases. Recently a report suggested that another metallopeptidase,glutamate carboxypeptidase II (GCPII), can also cleave A. GCPII is a zinc exopeptidase that cleaves glutamate from N-acetyl-l-aspartyl-l-glutamate in the central nervous system and from pteroylpoly--glutamate in the jejunum. GCPII has been proposed as apromising therapeutic target for disorders caused by glutamate neurotoxicity. However, an A-degrading activity of GCPII would compromise potential pharmaceutical use of GCPII inhibitors, because the enzyme inhibition might lead to increas

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/GAP304%2F12%2F0847" target="_blank" >GAP304/12/0847: Glutamate Carboxypeptidase II and its role in cancer development</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

FASEB Journal

ISSN

0892-6638

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

2626-2632

UT code for WoS article

000328841000012

EID of the result in the Scopus database

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