Can network analysis shed light on predictors of lithium response in bipolar I disorder?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F20%3A43920442" target="_blank" >RIV/00023752:_____/20:43920442 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1111/acps.13163" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/acps.13163</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/acps.13163" target="_blank" >10.1111/acps.13163</a>
Alternative languages
Result language
angličtina
Original language name
Can network analysis shed light on predictors of lithium response in bipolar I disorder?
Original language description
Objective To undertake a large-scale clinical study of predictors of lithium (Li) response in bipolar I disorder (BD-I) and apply contemporary multivariate approaches to account for inter-relationships between putative predictors. Methods We used network analysis to estimate the number and strength of connections between potential predictors of good Li response (measured by a new scoring algorithm for the Retrospective Assessment of Response to Lithium Scale) in 900 individuals with BD-I recruited to the Consortium of Lithium Genetics. Results After accounting for co-associations between potential predictors, the most important factors associated with the good Li response phenotype were panic disorder, manic predominant polarity, manic first episode, age at onset between 15-32 years and family history of BD. Factors most strongly linked to poor outcome were comorbid obsessive-compulsive disorder, alcohol and/or substance misuse, and/or psychosis (symptoms or syndromes). Conclusions Network analysis can offer important additional insights to prospective studies of predictors of Li treatment outcomes. It appears to especially help in further clarifying the role of family history of BD (i.e. its direct and indirect associations) and highlighting the positive and negative associations of different subtypes of anxiety disorders with Li response, particularly the little-known negative association between Li response and obsessive-compulsive disorder.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Psychiatrica Scandinavica
ISSN
0001-690X
e-ISSN
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Volume of the periodical
141
Issue of the periodical within the volume
6
Country of publishing house
DK - DENMARK
Number of pages
12
Pages from-to
522-533
UT code for WoS article
000538310300005
EID of the result in the Scopus database
2-s2.0-85081575803