Integrated phylogeny of the human brain and pathobiology of Alzheimer’s disease: A unifying hypothesis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F21%3A43920567" target="_blank" >RIV/00023752:_____/21:43920567 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/21:43921387
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0304394021002731?via%3Dihub#" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0304394021002731?via%3Dihub#</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.neulet.2021.135895" target="_blank" >10.1016/j.neulet.2021.135895</a>

Result language
angličtina
Original language name
Integrated phylogeny of the human brain and pathobiology of Alzheimer’s disease: A unifying hypothesis
Original language description
The disproportionate evolutionary expansion of the human cerebral cortex with reinforcement of cholinergic innervations warranted a major rise in the functional and metabolic load of the conserved basal forebrain (BF) cholinergic system. Given that acetylcholine (ACh) regulates properties of the microtubule-associated protein (MAP) tau and promotes non-amyloidogenic processing of amyloid precursor protein (APP), growing neocortex predicts higher demands for ACh, while the emerging role of BF cholinergic projections in Aβ clearance infers greater exposure of source neurons and their innervation fields to amyloid pathology. The higher exposure of evolutionary most recent cortical areas to the amyloid pathology of Alzheimer’s disease (AD) with synaptic impairments and atrophy, therefore, might involve attenuated homeostatic effects of BF cholinergic projections, in addition to fall-outs of inherent processes of expanding association areas. This unifying model, thus, views amyloid pathology and loss of cholinergic cells as a quid pro quo of the allometric evolution of the human brain, which in combination with increase in life expectancy overwhelm the fine homeostatic balance and trigger the disease process.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)

Project
<a href="/en/project/LO1611" target="_blank" >LO1611: Sustainability for The National Institute of Mental Health</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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