Endogenous antagonists of N‐methyl‐d‐aspartate receptor in schizophrenia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F21%3A43920568" target="_blank" >RIV/00023752:_____/21:43920568 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/21:43920865
Result on the web
<a href="https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.12244" target="_blank" >https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.12244</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/alz.12244" target="_blank" >10.1002/alz.12244</a>
Alternative languages
Result language
angličtina
Original language name
Endogenous antagonists of N‐methyl‐d‐aspartate receptor in schizophrenia
Original language description
Schizophrenia is a chronic neuropsychiatric brain disorder that has devastating personal impact and rising healthcare costs. Dysregulation of glutamatergic neurotransmission has been implicated in the pathobiology of the disease, attributed largely to the hypofunction of the N‐methyl‐d‐aspartate (NMDA) receptor. Currently, there is a major gap in mechanistic analysis as to how endogenous modulators of the NMDA receptors contribute to the onset and progression of the disease. We present a systematic review of the neurobiology and the role of endogenous NMDA receptor antagonists in animal models of schizophrenia, and in patients. We discuss their neurochemical origin, release from neurons and glia with action mechanisms, and functional effects, which might contribute toward the impairment of neuronal processes underlying this complex pathological state. We consider clinical evidence suggesting dysregulations of endogenous NMDA receptor in schizophrenia, and highlight the pressing need in future studies and emerging directions, to restore the NMDA receptor functions for therapeutic benefits.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/LO1611" target="_blank" >LO1611: Sustainability for The National Institute of Mental Health</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Alzheimer`s and Dementia
ISSN
1552-5260
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
18
Pages from-to
888-905
UT code for WoS article
000651096100014
EID of the result in the Scopus database
2-s2.0-85097671023