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Endogenous antagonists of N‐methyl‐d‐aspartate receptor in schizophrenia

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F21%3A43920568" target="_blank" >RIV/00023752:_____/21:43920568 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11120/21:43920865

  • Result on the web

    <a href="https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.12244" target="_blank" >https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.12244</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/alz.12244" target="_blank" >10.1002/alz.12244</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Endogenous antagonists of N‐methyl‐d‐aspartate receptor in schizophrenia

  • Original language description

    Schizophrenia is a chronic neuropsychiatric brain disorder that has devastating personal impact and rising healthcare costs. Dysregulation of glutamatergic neurotransmission has been implicated in the pathobiology of the disease, attributed largely to the hypofunction of the N‐methyl‐d‐aspartate (NMDA) receptor. Currently, there is a major gap in mechanistic analysis as to how endogenous modulators of the NMDA receptors contribute to the onset and progression of the disease. We present a systematic review of the neurobiology and the role of endogenous NMDA receptor antagonists in animal models of schizophrenia, and in patients. We discuss their neurochemical origin, release from neurons and glia with action mechanisms, and functional effects, which might contribute toward the impairment of neuronal processes underlying this complex pathological state. We consider clinical evidence suggesting dysregulations of endogenous NMDA receptor in schizophrenia, and highlight the pressing need in future studies and emerging directions, to restore the NMDA receptor functions for therapeutic benefits.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30103 - Neurosciences (including psychophysiology)

Result continuities

  • Project

    <a href="/en/project/LO1611" target="_blank" >LO1611: Sustainability for The National Institute of Mental Health</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Alzheimer`s and Dementia

  • ISSN

    1552-5260

  • e-ISSN

  • Volume of the periodical

    17

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    18

  • Pages from-to

    888-905

  • UT code for WoS article

    000651096100014

  • EID of the result in the Scopus database

    2-s2.0-85097671023