Review of Synthetic Approaches to Dizocilpine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F21%3A10426433" target="_blank" >RIV/00179906:_____/21:10426433 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/21:00556838
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=RZB6cVGR-B" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=RZB6cVGR-B</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1385272824999201230205835" target="_blank" >10.2174/1385272824999201230205835</a>
Alternative languages
Result language
angličtina
Original language name
Review of Synthetic Approaches to Dizocilpine
Original language description
N-Methyl-D-aspartate (NMDA) receptors, together with AMPA and kainite receptors, belong to the family of ionotropic glutamate receptors. NMDA receptors play a crucial role in neuronal plasticity and cognitive functions. Overactivation of those receptors leads to glutamate-induced excitotoxicity, which could be suppressed by NMDA antagonists. Dizocilpine was firstly reported in 1982 as an NMDA receptor antagonist with anticonvulsive properties, but due to serious side effects like neuronal vacuolization, its use in human medicine is restricted. However, dizocilpine is still used as a validated tool to induce the symptoms of schizophrenia in animal models and also as a standard for comparative purposes to newly developed NMDA receptor antagonists. For this reason, the synthesis of dizocilpine and especially its more active enantiomer (+)-dizocilpine is still relevant. In this review, we bring a collection of various synthetic approaches leading to dizocilpine and its analogues.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
<a href="/en/project/GA20-12047S" target="_blank" >GA20-12047S: Novel neuroprotective compounds based on NMDA receptor antagonism and cholinergic stimulation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Organic Chemistry
ISSN
1385-2728
e-ISSN
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Volume of the periodical
25
Issue of the periodical within the volume
5
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
21
Pages from-to
580-600
UT code for WoS article
000621718300003
EID of the result in the Scopus database
2-s2.0-85103842032