All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Review of Synthetic Approaches to Dizocilpine

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F21%3A10426433" target="_blank" >RIV/00179906:_____/21:10426433 - isvavai.cz</a>

  • Alternative codes found

    RIV/60162694:G44__/21:00556838

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=RZB6cVGR-B" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=RZB6cVGR-B</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2174/1385272824999201230205835" target="_blank" >10.2174/1385272824999201230205835</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Review of Synthetic Approaches to Dizocilpine

  • Original language description

    N-Methyl-D-aspartate (NMDA) receptors, together with AMPA and kainite receptors, belong to the family of ionotropic glutamate receptors. NMDA receptors play a crucial role in neuronal plasticity and cognitive functions. Overactivation of those receptors leads to glutamate-induced excitotoxicity, which could be suppressed by NMDA antagonists. Dizocilpine was firstly reported in 1982 as an NMDA receptor antagonist with anticonvulsive properties, but due to serious side effects like neuronal vacuolization, its use in human medicine is restricted. However, dizocilpine is still used as a validated tool to induce the symptoms of schizophrenia in animal models and also as a standard for comparative purposes to newly developed NMDA receptor antagonists. For this reason, the synthesis of dizocilpine and especially its more active enantiomer (+)-dizocilpine is still relevant. In this review, we bring a collection of various synthetic approaches leading to dizocilpine and its analogues.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10401 - Organic chemistry

Result continuities

  • Project

    <a href="/en/project/GA20-12047S" target="_blank" >GA20-12047S: Novel neuroprotective compounds based on NMDA receptor antagonism and cholinergic stimulation</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Current Organic Chemistry

  • ISSN

    1385-2728

  • e-ISSN

  • Volume of the periodical

    25

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    21

  • Pages from-to

    580-600

  • UT code for WoS article

    000621718300003

  • EID of the result in the Scopus database

    2-s2.0-85103842032