Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F21%3A43920614" target="_blank" >RIV/00023752:_____/21:43920614 - isvavai.cz</a>

Result on the web

<a href="https://www.nature.com/articles/s41588-021-00857-4" target="_blank" >https://www.nature.com/articles/s41588-021-00857-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41588-021-00857-4" target="_blank" >10.1038/s41588-021-00857-4</a>

Result language

angličtina

Original language name

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Original language description

Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. Bipolar disorder risk alleles were enriched in genes in synaptic signaling pathways and brain-expressed genes, particularly those with high specificity of expression in neurons of the prefrontal cortex and hippocampus. Significant signal enrichment was found in genes encoding targets of antipsychotics, calcium channel blockers, antiepileptics and anesthetics. Integrating expression quantitative trait locus data implicated 15 genes robustly linked to bipolar disorder via gene expression, encoding druggable targets such as HTR6, MCHR1, DCLK3 and FURIN. Analyses of bipolar disorder subtypes indicated high but imperfect genetic correlation between bipolar disorder type I and II and identified additional associated loci. Together, these results advance our understanding of the biological etiology of bipolar disorder, identify novel therapeutic leads and prioritize genes for functional follow-up studies.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30215 - Psychiatry

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature Genetics

ISSN

1061-4036

e-ISSN

—

Volume of the periodical

53

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

817-829

UT code for WoS article

000651382200001

EID of the result in the Scopus database

2-s2.0-85107422437