Several reasons why ketamine as a neuroplastic agent may have failed to prevent postoperative delirium: Implications for future protocols

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F23%3A43921098" target="_blank" >RIV/00023752:_____/23:43921098 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21230/23:00363337 RIV/00216224:90249/23:00133576 RIV/00216208:11120/23:43925094
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0304394023000496?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0304394023000496?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.neulet.2023.137095" target="_blank" >10.1016/j.neulet.2023.137095</a>

Result language
angličtina
Original language name
Several reasons why ketamine as a neuroplastic agent may have failed to prevent postoperative delirium: Implications for future protocols
Original language description
Ketamine exerts anti-inflammatory, neuroprotective and neuroplastic activity, therefore it may counteract the neurotoxic processes underlying postoperative delirium. However, the majority of studies in this field failed. We identified several pharmacological reasons why these studies may have failed, together with suggestions of how to remediate them. Among them, the interaction with intravenous general anesthetics exerting the opposite effect on GABA interneurons than ketamine may be of principal importance. We suggest biomarkers which may elucidate the influence of this interaction on the different steps of neuroplastic pathways. We hypothesize that administering ketamine before or after general anesthesia could both prevent the interactions and strengthen the effect of ketamine by timing surgery within the climax of ketamine-induced neuroplastic changes or by stabilizing AMPA receptors. It is vital to deal with these questions because the protocols of ongoing studies are based again on the administration of ketamine during general anesthesia (the major identified pitfall).
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30103 - Neurosciences (including psychophysiology)

Project
<a href="/en/project/NV18-04-00260" target="_blank" >NV18-04-00260: Clinical and neurobiological predictors of response to ketamine: towards personalized treatment of depression</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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