Participation of the nitric oxide pathway in lordosis induced by apelin-13 in female rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F23%3A43921174" target="_blank" >RIV/00023752:_____/23:43921174 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11240/23:10475290
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0018506X23001472?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0018506X23001472?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.yhbeh.2023.105449" target="_blank" >10.1016/j.yhbeh.2023.105449</a>
Alternative languages
Result language
angličtina
Original language name
Participation of the nitric oxide pathway in lordosis induced by apelin-13 in female rats
Original language description
The present study investigated the participation of the nitric oxide pathway in facilitating lordosis behavior induced by intrahypothalamic administration of apelin-13 in ovariectomized rats primed with estradiol benzoate (EB). The experiments involved the administration of a nitric oxide synthase inhibitor (L-NAME) or a nitric oxide-dependent, soluble guanylyl cyclase inhibitor (ODQ), and an inhibitor of protein kinase G (KT5823) to the ventromedial hypothalamus (VMH) of EB-primed rats 30 min before infusion of apelin-13 (0.75 μg/μl). This dose of apelin-13 consistently induces lordosis behavior at 30 min, 120 min, and 240 min following infusion. Results showed that injections of either L-NAME or KT5823 significantly reduced the lordosis induced by apelin at 120 and 240 min. However, VMH infusion of ODQ 30 min before apelin-13 infusion reduced but did not significantly inhibit, the lordosis elicited by this peptide at the same time points. We conclude that the nitric oxide pathway in the VMH plays an important role in lordosis induced by apelin-13 in EB-primed rats.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Hormones and Behavior
ISSN
0018-506X
e-ISSN
1095-6867
Volume of the periodical
156
Issue of the periodical within the volume
"Article number: 105449"
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
1-11
UT code for WoS article
001109088700001
EID of the result in the Scopus database
2-s2.0-85175493388