Oxytocin induces lordosis behavior in female rats through the prostaglandin E2/GnRH signaling system
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F21%3A43920763" target="_blank" >RIV/00023752:_____/21:43920763 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11240/21:10440630
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0018506X21001604?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0018506X21001604?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.yhbeh.2021.105081" target="_blank" >10.1016/j.yhbeh.2021.105081</a>
Alternative languages
Result language
angličtina
Original language name
Oxytocin induces lordosis behavior in female rats through the prostaglandin E2/GnRH signaling system
Original language description
Reaxys Chemistry database information SciVal Topics Metrics Funding details Abstract Intracerebroventricular (icv) administration of oxytocin (OT) induces robust lordosis behavior (lordosis quotient and lordosis intensity) in estrogen-primed rats. The present study explored the hypothesis that the OT-Prostaglandin E2-GnRH pathway (a pathway produced in astrocytes) is involved in the facilitation of lordosis behavior by icv infusion of OT (2 μg). In Experiment 1, we tested the involvement of the OT receptor (OTR) by infusion of the OTR antagonist, atosiban (ATO). OT-induced lordosis was significantly reduced at both 30 and 120 min by prior infusion of ATO. In Experiment 2, we studied the effects of aspirin (COX2 inhibitor) and ONO-AE3-208 (ONO; EP4 prostaglandin receptor antagonist) on OT-induced lordosis. Infusions of both compounds diminished OT-induced lordosis at both 120 and 240 min. In Experiment 3, the involvement of the GnRH-1 receptor inhibitor antide on OT-induced lordosis was evaluated. Antide significantly inhibited OT-induced lordosis at all times tested. These data indicate that the OT/PGE2/GnRH pathway is involved in the expression of OT-induced lordosis behavior, an effect that may be occurring directly in hypothalamic astrocytes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10614 - Behavioral sciences biology
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Hormones and Behavior
ISSN
0018-506X
e-ISSN
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Volume of the periodical
136
Issue of the periodical within the volume
November
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
"Article Number: 105081"
UT code for WoS article
000715115500004
EID of the result in the Scopus database
2-s2.0-85117762976