Participation of kisspeptin, progesterone, and GnRH receptors on lordosis behavior induced by kisspeptin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F24%3A43921302" target="_blank" >RIV/00023752:_____/24:43921302 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11240/24:10492168
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0031938424001549" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0031938424001549</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.physbeh.2024.114609" target="_blank" >10.1016/j.physbeh.2024.114609</a>
Alternative languages
Result language
angličtina
Original language name
Participation of kisspeptin, progesterone, and GnRH receptors on lordosis behavior induced by kisspeptin
Original language description
The neuropeptide kisspeptin (Kiss) is crucial in regulating the hypothalamic-pituitary-gonadal axis. It is produced by two main groups of neurons in the hypothalamus: the rostral periventricular region around the third ventricle and the arcuate nucleus. Kiss is the peptide product of the KiSS-1 gene and serves as the endogenous agonist for the GPR54 receptor. The Kiss/GPR54 system functions as a critical regulator of the reproductive system. Thus, we examined the effect of intracerebroventricular administration of 3 μg of Kiss to the right lateral ventricle of ovariectomized rats primed with a dose of 5 μg subcutaneous (sc) of estradiol benzoate (EB). Kiss treatment increased the lordosis quotient at all times tested. However, the lordosis reflex score was comparatively lower yet still significant compared to the control group. To investigate receptor specificity and downstream mechanisms on lordosis, we infused 10 μg of GPR54 receptor antagonist, Kiss-234, 5 μg of the progestin receptor antagonist, RU486, or 3 μg of antide, a gonadotropin-releasing hormone-1 (GnRH-1) receptor antagonist, to the right lateral ventricle 30 min before an infusion of 3 μg of Kiss. Results demonstrated a significant reduction in the facilitation of lordosis behavior by Kiss at 60 and 120 min when Kiss-234, RU486, or antide were administered. These findings suggest that Kiss stimulates lordosis expression by activating GPR54 receptors on GnRH neurons and that Kiss/GPR54 system is an essential intermediary by which progesterone activates GnRH.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiology & Behavior
ISSN
0031-9384
e-ISSN
1873-507X
Volume of the periodical
283
Issue of the periodical within the volume
"Article Number: 114609"
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
1-9
UT code for WoS article
001258629700001
EID of the result in the Scopus database
2-s2.0-85195855439