Glutamatergic abnormalities in the pregenual anterior cingulate cortex in obsessive-compulsive disorder using magnetic resonance spectroscopy: A controlled study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F23%3A43921216" target="_blank" >RIV/00023752:_____/23:43921216 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/23:43926108 RIV/00023001:_____/23:00084369

Result on the web

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0925492723001312?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0925492723001312?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pscychresns.2023.111721" target="_blank" >10.1016/j.pscychresns.2023.111721</a>

Result language

angličtina

Original language name

Glutamatergic abnormalities in the pregenual anterior cingulate cortex in obsessive-compulsive disorder using magnetic resonance spectroscopy: A controlled study

Original language description

In this study, we utilized proton magnetic resonance spectroscopy (MRS) to understand the role of glutamate (Glu), glutamine (Gln), and gamma-aminobutyric acid (GABA) of OCD patients in the pregenual anterior cingulate cortex (pgACC). In total, 54 patients with OCD and 54 healthy controls (HC) matched for age and sex were included in the study. They underwent MRS in the pgACC region to calculate the concentrations of Glu, Gln, GABA, and Glu + Gln (Glx). After quality control of the MRS data, 21 OCD and 21 HC were statistically analyzed. The severity of symptoms were evaluated using the Yale–Brown Obsessive-Compulsive Scale (YBOCS). In the statistical analysis, we compared differences between groups for the metabolites; in the OCD we analyzed the correlations with symptom severity, medication status, age, and duration of illness. A significant decrease in Glx, in Glu, and in Gln in the pgACC were observed in the OCD compared to HC. The correlation statistics showed a significant positive correlation between Glu levels and the YBOCS compulsions subscale. The results indicate that patients with OCD present a disturbance in glutamatergic metabolism in the pgACC. The results also demonstrate that these changes correlate with the severity of compulsions.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30215 - Psychiatry

Project

<a href="/en/project/NU20-04-00147" target="_blank" >NU20-04-00147: Obsessive-compulsive disorder as a decision-making disease: translational probe of aberrant error signalling and coordination of brain networks targeting causal interactions and clues for therapy.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Psychiatry Research-Neuroimaging

ISSN

0925-4927

e-ISSN

1872-7506

Volume of the periodical

335

Issue of the periodical within the volume

"Article number 111721"

Country of publishing house

IE - IRELAND

Number of pages

7

Pages from-to

1-7

UT code for WoS article

001099968500001

EID of the result in the Scopus database

2-s2.0-85173789627