GABA, glutamate dynamics and BOLD observed during cognitive processing in psychosis patients with hallucinatory traits
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F25%3A00637817" target="_blank" >RIV/67985807:_____/25:00637817 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1038/s41598-025-03644-x" target="_blank" >https://doi.org/10.1038/s41598-025-03644-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-025-03644-x" target="_blank" >10.1038/s41598-025-03644-x</a>
Alternative languages
Result language
angličtina
Original language name
GABA, glutamate dynamics and BOLD observed during cognitive processing in psychosis patients with hallucinatory traits
Original language description
The perception of a voice in the absence of an external auditory source—an auditory verbal hallucination—is a characteristic symptom of schizophrenia. To better understand this phenomenon requires integration of findings across behavioural, functional, and neurochemical levels. We address this with a locally adapted MEGA-PRESS sequence incorporating interleaved unsuppressed water acquisitions, allowing concurrent assessment of behaviour, blood-oxygenation-level-dependent (BOLD) functional changes, Glutamate + Glutamine (Glx), and GABA, synchronised with a cognitive (flanker) task. We acquired data from the anterior cingulate cortex (ACC) of 51 patients with psychosis (predominantly schizophrenia spectrum disorder) and hallucinations, matched to healthy controls. Consistent with the notion of an excitatory/inhibitory imbalance, we hypothesized differential effects for Glx and GABA between groups, and aberrant dynamics in response to task. Results showed impaired task performance, lower baseline Glx and positive association between Glx and BOLD in patients, contrasting a negative correlation in healthy controls. Task-related increases in Glx were observed in both groups, with no significant difference between groups. No significant effects were observed for GABA. These findings suggest that a putative excitatory/inhibitory imbalance affecting inhibitory control in the ACC is primarily observed as tonic, baseline glutamate differences, rather than GABAergic effects or aberrant dynamics in relation to a task.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
2045-2322
Volume of the periodical
15
Issue of the periodical within the volume
June 2025
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
19466
UT code for WoS article
001520517500023
EID of the result in the Scopus database
2-s2.0-105007159325