Influence of environmental enrichment on sexual behavior and the process of learning and memory in a rat model of autism with valproic acid
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F24%3A43921190" target="_blank" >RIV/00023752:_____/24:43921190 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11240/24:10475936
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0006899323005097" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0006899323005097</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.brainres.2023.148738" target="_blank" >10.1016/j.brainres.2023.148738</a>
Alternative languages
Result language
angličtina
Original language name
Influence of environmental enrichment on sexual behavior and the process of learning and memory in a rat model of autism with valproic acid
Original language description
Autism spectrum disorder (ASD) is a psychiatric disorder with severe behavioral consequences and no specifictherapy. Its etiology is multifactorial, as it is caused by a complex interaction of genetic and environmentalfactors. In rats, prenatal exposure to the antiepileptic drug valproic acid (VPA) has been associated with anincreased risk of autistic-like behaviors in offspring, including social behavior deficits, increased repetitive behaviors, and cognitive impairments. In addition, VPA-treated rats have shown altered sociosexual behaviors.However, the mechanisms underlying these alterations in reproductive processes in VPA-treated rats are not fullyunderstood. Interestingly some abnormal behaviors in VPA autism models are improved by an enriched environment (EE). In the present study, we examined the effects of EE on memory performance and sexual behaviorin male rats. We found that on postnatal day 90, EE reduced the time it took for both control and VPA-treatedgroups to find a hidden platform in the Morris water maze. On PND 100, prenatal exposure to VPA reduced totalexploring time in object recognition tests. On PND 110, EE reduced mount and intromission latency andincreased ejaculatory frequency in VPA-treated male rats. These results suggest that environmental stimulisignificantly influence the onset of sexual behavior in VPA-treated male rats and that EE may be a potential toolfor improving a variety of behavioral deficiencies in rodent models of autism.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Brain Research
ISSN
0006-8993
e-ISSN
1872-6240
Volume of the periodical
1827
Issue of the periodical within the volume
"Article number 148738"
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
1-8
UT code for WoS article
001153773100001
EID of the result in the Scopus database
2-s2.0-85181829082