Right ventrolateral and left dorsolateral 10 Hz transcranial magnetic stimulation as an add-on treatment for bipolar I and II depression: a double-blind, randomised, three‐arm, sham-controlled study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F24%3A43921303" target="_blank" >RIV/00023752:_____/24:43921303 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/24:43927058
Result on the web
<a href="https://www.tandfonline.com/doi/full/10.1080/15622975.2024.2357110" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/15622975.2024.2357110</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/15622975.2024.2357110" target="_blank" >10.1080/15622975.2024.2357110</a>
Alternative languages
Result language
angličtina
Original language name
Right ventrolateral and left dorsolateral 10 Hz transcranial magnetic stimulation as an add-on treatment for bipolar I and II depression: a double-blind, randomised, three‐arm, sham-controlled study
Original language description
Objectives: Despite the clinical importance of bipolar depression (BDE), effective treatment options are still limited. Transcranial magnetic stimulation (rTMS) has proven of moderate efficacy in major depression, but the evidence remains inconclusive for BDE. Methods: A 4-week, double-blind, randomised, parallel-group, sham-controlled study (trial ID ISRCTN77188420) explored the benefits of 10 Hz MRI-guided right ventrolateral (RVL) rTMS and left dorsolateral (LDL) rTMS as add-on treatments for BDE. Outcome measures included changes in the Montgomery-Åsberg Depression Rating Scale (MADRS) score, self-assessment, response and remission rates, and side effects. Results: Sixty patients were randomly assigned to study groups, and forty-six completed the double-blind phase. The mean change from baseline to Week 4 in MADRS was greater in both active groups compared to the sham, yet differences did not achieve significance (RVL vs sham: −4.50, 95%CI −10.63 to 1.64, p = 0.3; LDL vs sham: −4.07, 95%CI −10.24 to 2.10, p = 0.4). None of the other outcome measures yielded significant results. Conclusions: While not demonstrating the superiority of either 10 Hz rTMS over sham, with the limited sample size, we can not rule out a moderate yet clinically meaningful effect. Further well-powered studies are essential to elucidate the role of rTMS in managing BDE.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
World Journal of Biological Psychiatry
ISSN
1562-2975
e-ISSN
1814-1412
Volume of the periodical
25
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
304-316
UT code for WoS article
001230969600001
EID of the result in the Scopus database
2-s2.0-85194478220