Cerebellar impairments in genetic models of autism spectrum disorders: A neurobiological perspective

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F24%3A43921387" target="_blank" >RIV/00023752:_____/24:43921387 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/24:43927744

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0301008224001217?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0301008224001217?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pneurobio.2024.102685" target="_blank" >10.1016/j.pneurobio.2024.102685</a>

Result language

angličtina

Original language name

Cerebellar impairments in genetic models of autism spectrum disorders: A neurobiological perspective

Original language description

Functional and molecular alterations in the cerebellum are among the most widely recognised associates of autism spectrum disorders (ASD). As a critical computational hub of the brain, the cerebellum controls and coordinates a range of motor, affective and cognitive processes. Despite well-described circuits and integrative mechanisms, specific changes that underlie cerebellar impairments in ASD remain elusive. Studies in experimental animals have been critical in uncovering molecular pathology and neuro-behavioural correlates, providing a model for investigating complex disease conditions. Herein, we review commonalities and differences of the most extensively characterised genetic lines of ASD with reference to the cerebellum. We revisit structural, functional, and molecular alterations which may contribute to neurobehavioral phenotypes. The cross-model analysis of this study provides an integrated outlook on the role of cerebellar alterations in pathobiology of ASD that may benefit future translational research and development of therapies.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Progress in Neurobiology

ISSN

0301-0082

e-ISSN

1873-5118

Volume of the periodical

242

Issue of the periodical within the volume

"Article Number: 102685"

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

1-14

UT code for WoS article

001357124000001

EID of the result in the Scopus database

2-s2.0-85208562335