The mystery of the cerebellum: clues from experimental and clinical observations

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00070197" target="_blank" >RIV/00159816:_____/18:00070197 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/18:00103454

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877388/pdf/40673_2018_Article_87.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877388/pdf/40673_2018_Article_87.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s40673-018-0087-9" target="_blank" >10.1186/s40673-018-0087-9</a>

Result language

angličtina

Original language name

The mystery of the cerebellum: clues from experimental and clinical observations

Original language description

The cerebellum has a striking homogeneous cytoarchitecture and participates in both motor and non-motor domains. Indeed, a wealth of evidence from neuroanatomical, electrophysiological, neuroimaging and clinical studies has substantially modified our traditional view on the cerebellum as a sole calibrator of sensorimotor functions. Despite the major advances of the last four decades of cerebellar research, outstanding questions remain regarding the mechanisms and functions of the cerebellar circuitry. We discuss major clues from both experimental and clinical studies, with a focus on rodent models in fear behaviour, on the role of the cerebellum in motor control, on cerebellar contributions to timing and our appraisal of the pathogenesis of cerebellar tremor. The cerebellum occupies a central position to optimize behaviour, motor control, timing procedures and to prevent body oscillations. More than ever, the cerebellum is now considered as a major actor on the scene of disorders affecting the CNS, extending from motor disorders to cognitive and affective disorders. However, the respective roles of the mossy fibres, the climbing fibres, cerebellar cortex and cerebellar nuclei remains unknown or partially known at best in most cases. Research is now moving towards a better definition of the roles of cerebellar modules and microzones. This will impact on the management of cerebellar disorders.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cerebellum &amp; Ataxias

ISSN

2053-8871

e-ISSN

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Volume of the periodical

5

Issue of the periodical within the volume

8

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

"nestr."

UT code for WoS article

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EID of the result in the Scopus database

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