No evidence of Alzheimer’s disease pathology in mice infected with Toxocara canis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F25%3A43921511" target="_blank" >RIV/00023752:_____/25:43921511 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/25:00619132 RIV/00216208:11110/25:10497939 RIV/00216208:11160/25:10497939 RIV/00216208:11310/25:10497939
Result on the web
<a href="https://www.parasite-journal.org/articles/parasite/full_html/2025/01/parasite250018/parasite250018.html" target="_blank" >https://www.parasite-journal.org/articles/parasite/full_html/2025/01/parasite250018/parasite250018.html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1051/parasite/2025019" target="_blank" >10.1051/parasite/2025019</a>
Alternative languages
Result language
angličtina
Original language name
No evidence of Alzheimer’s disease pathology in mice infected with Toxocara canis
Original language description
The potential link between the infections and the development of Alzheimer’s disease (AD) has led to speculations about the role of various pathogens in triggering amyloid-β (Aβ) overproduction, possibly leading to AD onset. The globally distributed dog roundworm Toxocara canis was suggested to be a suitable candidate due to neurotropism of the larvae and infection chronicity. This study investigated whether chronic T. canis infection induces AD-like pathology in mice and whether Aβ is toxic to T. canis. BALB/c and APP/PS1 transgenic mice, which overproduce Aβ, were infected with T. canis L3 larvae and monitored for larval burden, Aβ accumulation, and behavioral changes. In vitro tests of recombinant Aβ toxicity against the larvae were also performed. Despite the presence of T. canis larvae in the central nervous system 8 and 16 weeks post-infection, no significant increase in Aβ concentration or AD-related behavioral alterations were observed. Aβ was detected on the surface and within the intestines of T. canis larvae, but in vitro exposure to recombinant Aβ did not affect larval viability or morphology. Our findings suggest that T. canis infection does not trigger AD-like pathology in mice, and Aβ does not act as an antiparasitic agent. This challenges the emerging hypothesis that chronic neurotoxocarosis infections may contribute to AD development.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30310 - Parasitology
Result continuities
Project
<a href="/en/project/LM2023050" target="_blank" >LM2023050: National Infrastructure for Biological and Medical Imaging</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Parasite
ISSN
1252-607X
e-ISSN
1776-1042
Volume of the periodical
32
Issue of the periodical within the volume
"Article Number 24"
Country of publishing house
FR - FRANCE
Number of pages
12
Pages from-to
1-12
UT code for WoS article
001463591000002
EID of the result in the Scopus database
2-s2.0-105003080337