Effects of Clozapine, Haloperidol, and the NMDA Antagonist Ketamine on Novel Object Recognition in Gnathonemus petersii: A New Possible Model for Schizophrenia Research

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F25%3A43921514" target="_blank" >RIV/00023752:_____/25:43921514 - isvavai.cz</a>

Alternative codes found

RIV/60460709:41210/25:102707 RIV/68407700:21230/25:00384591 RIV/00216208:11120/25:43928560 RIV/00216208:11310/25:10498643 RIV/60461373:22330/25:43932733

Result on the web

<a href="https://www.mdpi.com/2410-3888/10/5/229" target="_blank" >https://www.mdpi.com/2410-3888/10/5/229</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/fishes10050229" target="_blank" >10.3390/fishes10050229</a>

Result language

angličtina

Original language name

Effects of Clozapine, Haloperidol, and the NMDA Antagonist Ketamine on Novel Object Recognition in Gnathonemus petersii: A New Possible Model for Schizophrenia Research

Original language description

first_pagesettingsOrder Article ReprintsOpen AccessArticleEffects of Clozapine, Haloperidol, and the NMDA Antagonist Ketamine on Novel Object Recognition in Gnathonemus petersii: A New Possible Model for Schizophrenia Researchby Petra Horká 1ORCID,Josefina Mavrogeni 1,Veronika Langová 2,3,Pavel Horký 4,*,Jan Hubený 2,Ivana Chrtková 2,5,Karel Valeš 2,Martin Kuchař 6ORCID andJiří Horáček 2,31Institute for Environmental Studies, Faculty of Science, Charles University, Benátská 2, 128 01 Prague, Czech Republic2National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic3Third Faculty of Medicine, Charles University, Ruská 87, 100 00 Prague, Czech Republic4Department of Zoology and Fisheries, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamýcká 129, Suchdol, 165 21 Prague, Czech Republic5Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Jugoslávských partyzánů 1580/3, 160 00 Prague, Czech Republic6Forensic Laboratory of Biologically Active Compounds, Department of Chemistry of Natural Compounds, University of Chemistry and Technology, Technická 3, 166 28 Prague, Czech Republic*Author to whom correspondence should be addressed.Fishes 2025, 10(5), 229; https://doi.org/10.3390/fishes10050229Submission received: 23 March 2025 / Revised: 9 May 2025 / Accepted: 9 May 2025 / Published: 15 May 2025Downloadkeyboard_arrow_down Browse Figures Versions NotesAbstractIn animal models, ketamine, a non-competitive N-methyl-D-aspartate (NMDA) antagonist, induces schizophrenia-like symptoms, such as positive and negative symptoms, as well as cognitive deficits. In the present study, we evaluated the behavioral responses and the number of EODs (electric organ discharges) of the weakly electric fish Gnathonemus petersii using the novel object recognition task (NORT). We aimed to investigate whether pharmacological modulation of the glutamatergic system would impair cognitive functions by administering the NMDA receptor antagonist ketamine, and whether these impairments could be suppressed by the administration of typical (first-generation) and atypical (second-generation) antipsychotics—clozapine and haloperidol, respectively. G. petersii preferred the familiar object over the novel object in the NORT paradigm. Although no significant differences were observed when exploring the two identical objects during the training session, the fish spent less time, moved a shorter distance, and emitted fewer EODs in the testing phase with the novel object. No direct relationship was detected between the EODs and behavioral responses to the administration of ketamine and typical antipsychotics. Ketamine administered with atypical antipsychotic clozapine disrupted the perception of the original object, where one of the objects was preferred. In the novel object trial, the time spent on the original and new objects was attenuated to the same level.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

<a href="/en/project/NU21-04-00405" target="_blank" >NU21-04-00405: Novel model of schizophrenia based on Gnathonemus petersii species enriched by the electrical communication and social behaviour evaluation</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Fishes

ISSN

2410-3888

e-ISSN

2410-3888

Volume of the periodical

10

Issue of the periodical within the volume

5

Country of publishing house

CH - SWITZERLAND

Number of pages

15

Pages from-to

229

UT code for WoS article

001496083500001

EID of the result in the Scopus database

2-s2.0-105006532275