Ketamine disrupts locomotion and electrolocation in a novel model of schizophrenia, Gnathonemus petersii fish
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F23%3A43921056" target="_blank" >RIV/00023752:_____/23:43921056 - isvavai.cz</a>
Alternative codes found
RIV/00216224:90249/23:00133574 RIV/00216208:11310/23:10457601 RIV/00216208:11120/23:43925212
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/jnr.25186" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/jnr.25186</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jnr.25186" target="_blank" >10.1002/jnr.25186</a>
Alternative languages
Result language
angličtina
Original language name
Ketamine disrupts locomotion and electrolocation in a novel model of schizophrenia, Gnathonemus petersii fish
Original language description
The present study aimed to examine a weakly electric fish Gnathonemus petersii (G. petersii) as a candidate model organism of glutamatergic theory of schizophrenia. The idea of G. petersii elevating the modeling of schizophrenia symptoms is based on the fish's electrolocation and electrocommunication abilities. Fish were exposed to the NMDA antagonist ketamine in two distinct series differing in the dose of ketamine. The main finding revealed ketamine-induced disruption of the relationship between electric signaling and behavior indicating impairment of fish navigation. Moreover, lower doses of ketamine significantly increased locomotion and erratic movement and higher doses of ketamine reduced the number of electric organ discharges indicating successful induction of positive schizophrenia-like symptoms and disruption of fish navigation. Additionally, a low dose of haloperidol was used to test the normalization of the positive symptoms to suggest a predictive validity of the model. However, although successfully induced, positive symptoms were not normalized using the low dose of haloperidol; hence, more doses of the typical antipsychotic haloperidol and probably also of a representative of atypical antipsychotic drugs need to be examined to confirm the predictive validity of the model.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neuroscience Research
ISSN
0360-4012
e-ISSN
1097-4547
Volume of the periodical
101
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
1098-1106
UT code for WoS article
000943024600001
EID of the result in the Scopus database
2-s2.0-85150229324