The Role of Zebrafish and Laboratory Rodents in Schizophrenia Research
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F20%3A43920293" target="_blank" >RIV/00023752:_____/20:43920293 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/20:43920585 RIV/00216208:11310/20:10415436
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fpsyt.2020.00703/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fpsyt.2020.00703/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fpsyt.2020.00703" target="_blank" >10.3389/fpsyt.2020.00703</a>
Alternative languages
Result language
angličtina
Original language name
The Role of Zebrafish and Laboratory Rodents in Schizophrenia Research
Original language description
Schizophrenia is a severe disorder characterized by positive, negative and cognitive symptoms, which are still not fully understood. The development of efficient antipsychotics requires animal models of a strong validity, therefore the aims of the article were to summarize the construct, face and predictive validity of schizophrenia models based on rodents and zebrafish, to compare the advantages and disadvantages of these models, and to propose future directions in schizophrenia modeling and indicate when it is reasonable to combine these models. The advantages of rodent models stem primarily from the high homology between rodent and human physiology, neurochemistry, brain morphology and circuitry. The advantages of zebrafish models stem in the high fecundity, fast development and transparency of the embryo. Disadvantages of both models originate in behavioral repertoires not allowing specific symptoms to be modeled, even when the models are combined. Especially modeling the verbal component of certain positive, negative and cognitive symptoms is currently impossible.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Psychiatry
ISSN
1664-0640
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
August
Country of publishing house
CH - SWITZERLAND
Number of pages
22
Pages from-to
703
UT code for WoS article
000573643400001
EID of the result in the Scopus database
2-s2.0-85091198714