A Comprehensive Review of Selenium as a Key Regulator in Thyroid Health
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F25%3A43921529" target="_blank" >RIV/00023752:_____/25:43921529 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/25:10515726
Result on the web
<a href="https://link.springer.com/article/10.1007/s12011-025-04653-7" target="_blank" >https://link.springer.com/article/10.1007/s12011-025-04653-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s12011-025-04653-7" target="_blank" >10.1007/s12011-025-04653-7</a>
Alternative languages
Result language
angličtina
Original language name
A Comprehensive Review of Selenium as a Key Regulator in Thyroid Health
Original language description
Selenium (Se) is an essential trace element crucial for thyroid function, participating in the production and metabolism of thyroid hormones and the immune system. It engages in synthesizing selenoproteins, which are essential for antioxidant defense and regulating thyroid hormone levels. It is crucial to convert thyroxine (T4) into the active thyroid hormone triiodothyronine (T3) via deiodinase activity and safeguard thyroid cells from oxidative damage. Therefore, thyroid dysfunction, including abnormalities in thyroid hormone synthesis and the emergence of autoimmune thyroid conditions such as Graves’ disease and Hashimoto’s thyroiditis, has been linked to Se deficiency. When evaluating the benefits of Se supplementation, it is crucial to recognize that excessive mineral intake may be detrimental and result in adverse consequences, including gastrointestinal disturbances and neurological problems. The effectiveness of Se-based therapies is influenced by individual characteristics, including hereditary anomalies in thyroid function and Se metabolism. Further research should be performed on personalized Se supplementation approaches using genetics and nanotechnology to optimize the bioavailability and efficacy of the supplements. This study aims to thoroughly examine Se’s role in thyroid health and how its therapeutic use in thyroid-related diseases may be optimized via appropriate dosing.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biological Trace Element Research
ISSN
0163-4984
e-ISSN
1559-0720
Volume of the periodical
203
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
6466-6480
UT code for WoS article
001494234600001
EID of the result in the Scopus database
2-s2.0-105004905803