Prediction of Treatment Outcome in Bipolar Disorder: When Can We Expect Clinical Relevance?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F25%3A43921530" target="_blank" >RIV/00023752:_____/25:43921530 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0006322325001039?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0006322325001039?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.biopsych.2025.02.005" target="_blank" >10.1016/j.biopsych.2025.02.005</a>
Alternative languages
Result language
angličtina
Original language name
Prediction of Treatment Outcome in Bipolar Disorder: When Can We Expect Clinical Relevance?
Original language description
Long-term pharmacological treatment is the cornerstone of the management of bipolar disorder (BD). Clinicians typically select mood-stabilizing medications from among several options through trial and error. This process could be optimized by using robust predictors of treatment response. We review clinical features and biological markers studied in relation to outcome of long-term treatment of BD. To date, the literature focuses mostly on lithium and to a lesser extent on the anticonvulsants valproate and lamotrigine. The most promising results show association of lithium response with certain clinical features (episodic clinical course and absence of rapid cycling, low rates of comorbid conditions, family history of BD and lithium response) as well as low polygenic risk for schizophrenia and major depression. The clinical application of these findings remains limited, however, due to heterogeneity of the illness as well as unanswered questions about specificity of the effects of different medications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biological Psychiatry
ISSN
0006-3223
e-ISSN
1873-2402
Volume of the periodical
98
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
285-292
UT code for WoS article
001578013300006
EID of the result in the Scopus database
2-s2.0-105002027092