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Reduced Sulfotransferase SULT2A1 Activity in Patients With Alzheimer´s Disease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023761%3A_____%2F15%3A%230000573" target="_blank" >RIV/00023761:_____/15:#0000573 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11120/15:43910502 RIV/00216208:11110/15:10313568 RIV/00216208:11240/15:10313568 RIV/00064190:_____/15:#0001073 RIV/00064165:_____/15:10313568

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Reduced Sulfotransferase SULT2A1 Activity in Patients With Alzheimer´s Disease

  • Original language description

    Steroids are important components in the pathophysiology of Alzheimer's disease (AD). Although their role has been studied, the corresponding metabolomic data is limited. In the present study we evaluate the role of steroid sulfotransferase SULT2A1 in the pathophysiology of AD on the basis of circulating steroids (measured by GC-MS), in which the sulfation catalyzed by SULT2A1 dominates over glucuronidation (pregnenolone/sulfate, DHEA/sulfate, androstenediol/sulfate and 5alpha-reduced pregnane and androstane catabolites).

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    ED - Physiology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NT13543" target="_blank" >NT13543: Study of Common Pathogenetic Factors of Alzheimer Disease and Type 2 Diabetes Mellitus</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Physiological Research

  • ISSN

    0862-8408

  • e-ISSN

  • Volume of the periodical

    64

  • Issue of the periodical within the volume

    Suppl.2

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    9

  • Pages from-to

    "S265"-"S273"

  • UT code for WoS article

    000365011800022

  • EID of the result in the Scopus database