Steroid Sulfation in Neurodegenerative Diseases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023761%3A_____%2F22%3AN0000014" target="_blank" >RIV/00023761:_____/22:N0000014 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/22:10442909 RIV/00216208:11110/22:10442909

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fmolb.2022.839887/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fmolb.2022.839887/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fmolb.2022.839887" target="_blank" >10.3389/fmolb.2022.839887</a>

Result language

angličtina

Original language name

Steroid Sulfation in Neurodegenerative Diseases

Original language description

Steroid sulfation and desulfation participates in the regulation of steroid bioactivity, metabolism and transport. The authors focused on sulfation and desulfation balance in three neurodegenerative diseases: Alzheimer ' s disease (AD), Parkinson ' s disease (PD), and multiple sclerosis (MS). Circulating steroid conjugates dominate their unconjugated counterparts, but unconjugated steroids outweigh their conjugated counterparts in the brain. Apart from the neurosteroid synthesis in the central nervous system (CNS), most brain steroids cross the blood-brain barrier (BBB) from the periphery and then may be further metabolized. Therefore, steroid levels in the periphery partly reflect the situation in the brain. The CNS steroids subsequently influence the neuronal excitability and have neuroprotective, neuroexcitatory, antidepressant and memory enhancing effects. They also exert anti-inflammatory and immunoprotective actions. Like the unconjugated steroids, the sulfated ones modulate various ligand-gated ion channels. Conjugation by sulfotransferases increases steroid water solubility and facilitates steroid transport. Steroid sulfates, having greater half-lives than their unconjugated counterparts, also serve as a steroid stock pool. Sulfotransferases are ubiquitous enzymes providing massive steroid sulfation in adrenal zona reticularis and zona fasciculata.. Steroid sulfatase hydrolyzing the steroid conjugates is exceedingly expressed in placenta but is ubiquitous in low amounts including brain capillaries of BBB which can rapidly hydrolyze the steroid sulfates coming across the BBB from the periphery. Lower dehydroepiandrosterone sulfate (DHEAS) plasma levels and reduced sulfotransferase activity are considered as risk factors in AD patients. The shifted balance towards unconjugated steroids can participate in the pathophysiology of PD and anti-inflammatory effects of DHEAS may counteract the MS.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/NU20-04-00450" target="_blank" >NU20-04-00450: Hormonal alterations in patients with multiple sclerosis</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Molecular Biosciences

ISSN

2296-889X

e-ISSN

2296-889X

Volume of the periodical

9

Issue of the periodical within the volume

February

Country of publishing house

CH - SWITZERLAND

Number of pages

16

Pages from-to

Article Number 839887

UT code for WoS article

000766878200001

EID of the result in the Scopus database

2-s2.0-85126249234