Efficacy and safety of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023761%3A_____%2F16%3AN0000016" target="_blank" >RIV/00023761:_____/16:N0000016 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10333719 RIV/00216208:11130/16:10333719 RIV/61989592:15120/16:33159224 RIV/00064203:_____/16:10333719 RIV/00064165:_____/16:10333719

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Efficacy and safety of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy

Original language description

Patients with intrahepatic cholestasis of pregnancy (ICP) benefit from ursodeoxycholic acid (UDCA) treatment. Since there is still certain reluctance to use UDCA in pregnant women, mainly due to warnings in the official SPC information in respective drug leaflets, our objective was to assess the efficacy and safety of UDCA during pregnancy. Our retrospective multicentric study was performed on 191 consecutive pregnant women with ICP treated with UDCA. Any maternal and/or fetal complications of the UDCA treatment were searched for; healthy pregnant women (n = 256) served as controls. The UDCA treatment improved liver disease status in the majority of the affected women (86.1%). This treatment was well tolerated, with only negligible skin reactions (0.5%) and mild diarrhea (4.7%). No complications attributable to UDCA treatment were detected during the fetal life, delivery, or the early neonatal period. We confirmed the good efficacy and safety of UDCA treatment in pregnancy for both mothers and fetuses/neonates.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FK - Gynaecology and obstetrics

OECD FORD branch

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Project

<a href="/en/project/NT12211" target="_blank" >NT12211: Prediction of termination of pregnancy in women with serious hepatopathies</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Annals of Hepatology

ISSN

1665-2681

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

5

Country of publishing house

MX - MEXICO

Number of pages

5

Pages from-to

757-761

UT code for WoS article

000397061200013

EID of the result in the Scopus database

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