Chromogranin A in the Laboratory Diagnosis of Pheochromocytoma and Paraganglioma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023761%3A_____%2F19%3AN0000006" target="_blank" >RIV/00023761:_____/19:N0000006 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10394371 RIV/00216208:11130/19:10394371 RIV/00064203:_____/19:10394371 RIV/00064165:_____/19:10394371

Result on the web

<a href="https://www.mdpi.com/2072-6694/11/4/586/htm" target="_blank" >https://www.mdpi.com/2072-6694/11/4/586/htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cancers11040586" target="_blank" >10.3390/cancers11040586</a>

Result language

angličtina

Original language name

Chromogranin A in the Laboratory Diagnosis of Pheochromocytoma and Paraganglioma

Original language description

This work discusses the clinical performance of chromogranin A (CGA), a commonly measured marker in neuroendocrine neoplasms, for the diagnosis of pheochromocytoma/paraganglioma (PPGL). Plasma CGA (cut-off value 150 mu g/L) was determined by an immunoradiometric assay. Free metanephrine (cut-off value 100 ng/L) and normetanephrine (cut-off value 170 ng/L) were determined by radioimmunoassay. Blood samples were collected from PPGL patients preoperatively, one week, six months, one year and two years after adrenal gland surgery. The control patients not diagnosed with PPGL suffered from adrenal problems or from MEN2 and thyroid carcinoma. The clinical sensitivity in the PPGL group of patients (n = 71) based on CGA is 90% and is below the clinical sensitivity determined by metanephrines (97%). The clinical specificity based on all plasma CGA values after surgery (n = 98) is 99% and is the same for metanephrines assays. The clinical specificity of CGA in the control group (n = 85) was 92% or 99% using metanephrines tests. We can conclude that plasma CGA can serve as an appropriate complement to metanephrines assays in laboratory diagnosis of PPGL patients. CGA is elevated in PPGLs, as well as in other neuroendocrine or non-neuroendocrine neoplasia and under clinical conditions increasing adrenergic activity.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

CANCERS

ISSN

2072-6694

e-ISSN

2072-6694

Volume of the periodical

11

Issue of the periodical within the volume

4

Country of publishing house

CH - SWITZERLAND

Number of pages

15

Pages from-to

nestrankovano

UT code for WoS article

000467773400154

EID of the result in the Scopus database

2-s2.0-85068458095