Radioimmunoassay of Chromogranin A and Free Metanephrines in Diagnosis of Pheochromocytoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10364716" target="_blank" >RIV/00216208:11110/17:10364716 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/17:10364716 RIV/00023761:_____/17:N0000030 RIV/00064203:_____/17:10364716 RIV/00064165:_____/17:10364716

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/66/66_S397.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/66/66_S397.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Radioimmunoassay of Chromogranin A and Free Metanephrines in Diagnosis of Pheochromocytoma

Original language description

This work discusses the clinical performance of chromogranin A, free metanephrine and normetanephrine determination in plasma using a radioimmunoanalytical methods for the diagnosis of pheochromocytoma and paraganglioma. Blood samples were collected from 55 patients (46 pheochromocytomas, 9 paragangliomas). A sampling of biological materials was performed preoperatively and about one week, six months and one year after adrenal gland surgery. The comparative group without a diagnosis of pheochromocytoma/paraganglioma consisted of 36 pheochromocytoma/paraganglioma patients more than 4 months after adrenal gland surgery, and of 87 patients, 16 of them with multiple endocrine neoplasia, 9 with medullary and 5 with parafolicullar carcinoma of the thyroid gland. The rest were patients with various adrenal gland disorders. Chromogranin A, metanephrine and normetanephrine were determined in the EDTA-plasma using a radioimmunoassay kits Cisbio Bioassays, France and IBL International GmbH, Germany. Clinical sensitivity was 96 % for the combination of metanephrine and normetanephrine, and 93 % for chromogranin A. Clinical specificity was 100 % for the combination metanephrine and normetanephrine, and 96 % for chromogranin A. Falsely elevated levels of chromogranin A were observed in 1 patient with chronic renal insufficiency and 9 analyses were influenced by the administration of proton pump inhibitors. These results were excluded of CGA specificity. Both the combination of plasma free metanephrine, normetanephrine and chromogranin A as determined by radioimmunoassays, which are simple without the necessity of special laboratory material, are effective markers of pheochromocytoma or paraganglioma. Chromogranin A exerts association to malignity and all markers are associated with tumor mass.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/NT12336" target="_blank" >NT12336: Chromogranin, metanephrines and thyroid factors in the differential diagnosis of neuroendocrine tumors directed to the medullary carcinoma of the thyroid gland and pheochromocytoma</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

66

Issue of the periodical within the volume

Suppl. 3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

12

Pages from-to

"S397"-"S408"

UT code for WoS article

000412737900014

EID of the result in the Scopus database

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