FADS1 gene polymorphism(s) and fatty acid composition of serum lipids in adolescents
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023761%3A_____%2F21%3AN0000017" target="_blank" >RIV/00023761:_____/21:N0000017 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10429417
Result on the web
<a href="https://aocs.onlinelibrary.wiley.com/doi/epdf/10.1002/lipd.12317" target="_blank" >https://aocs.onlinelibrary.wiley.com/doi/epdf/10.1002/lipd.12317</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/lipd.12317" target="_blank" >10.1002/lipd.12317</a>
Alternative languages
Result language
angličtina
Original language name
FADS1 gene polymorphism(s) and fatty acid composition of serum lipids in adolescents
Original language description
Polyunsaturated fatty acids (PUFA) influence many physiological functions. Associations have been found between single nucleotide polymorphisms (SNP) in the FADS1 (Fatty acid desaturase 1) gene and the relative abundance of PUFA in serum lipids. This study examines the relationship between two SNPs in the FADS1 gene (rs174546, rs174537) and the fatty acid (FA) composition of serum lipids in adolescents (13-18 years). We used DNA samples (670 children; 336 girls and 334 boys) from the Childhood Obesity Prevalence and Treatment (COPAT) project. Genomic DNA was extracted from peripheral blood leukocytes in whole blood samples. For genotype analysis, TaqMan SNP Genotyping assays (Applied Biosystems) were used. Fatty acid composition of serum lipids was assessed using gas chromatography. The T-statistic and regression were used for statistical evaluations. Minor allele T carriers in both SNPs had significant lower level of palmitic acid (16:0, phospholipids) and arachidonic acid (20:4[n-6], phospholipids) in both sexes. In girls, we found a significant positive association between minor allele T carriers and eicosadienoic acid (20:2[n-6], cholesteryl esters) in both SNPs. Being a minor allele T carrier was significantly positively associated with dihomo-gamma-linolenic acid (20:3[n-6], phospholipids) in boys in both SNPs. SNPs (including rs174546, rs174537) in the FADS gene cluster should have impacted desaturase activity, which may contribute to different efficiency of PUFA synthesis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30308 - Nutrition, Dietetics
Result continuities
Project
<a href="/en/project/NV17-31670A" target="_blank" >NV17-31670A: Lifestyle and cardiometabolic risks in Czech children and young adults: cross-sectional and prospective studies.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
LIPIDS
ISSN
0024-4201
e-ISSN
1558-9307
Volume of the periodical
56
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
499-508
UT code for WoS article
000668058600001
EID of the result in the Scopus database
2-s2.0-85108944228