The rs10830963 Polymorphism of the MTNR1B Gene: Association With Abnormal Glucose, Insulin and C-peptide Kinetics

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023761%3A_____%2F22%3AN0000012" target="_blank" >RIV/00023761:_____/22:N0000012 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/22:00558030 RIV/00064165:_____/22:10445143

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207528/pdf/fendo-13-868364.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207528/pdf/fendo-13-868364.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fendo.2022.868364" target="_blank" >10.3389/fendo.2022.868364</a>

Result language

angličtina

Original language name

The rs10830963 Polymorphism of the MTNR1B Gene: Association With Abnormal Glucose, Insulin and C-peptide Kinetics

Original language description

The MTNR1B gene encodes a receptor for melatonin, a hormone regulating biorhythms. Disruptions in biorhythms contribute to the development of type 2 diabetes mellitus (T2DM). Genetic studies suggest that variability in the MTNR1B gene affects T2DM development. Our aim was to compare the distribution of the genetic variant rs10830963 between persons differing in glucose tolerance in a sample of the Czech population (N=1206). We also evaluated possible associations of the polymorphism with insulin sensitivity, beta cell function, with the shape of glucose, insulin and C-peptide trajectories measured 7 times during a 3-hour oral glucose tolerance test (OGTT) and with glucagon response. In a subgroup of 268 volunteers we also evaluated sleep patterns and biorhythm. Results13 persons were diagnosed with T2DM, 119 had impaired fasting blood glucose (IFG) and/or impaired glucose tolerance (IGT). 1074 participants showed normal results and formed a control group. A higher frequency of minor allele G was found in the IFG/IGT group in comparison with controls. The GG constellation was present in 23% of diabetics, in 17% of IFG/IGT probands and in 11% of controls. Compared to CC and CG genotypes, GG homozygotes showed higher stimulated glycemia levels during the OGTT. Homozygous as well as heterozygous carriers of the G allele showed lower very early phase of insulin and C-peptide secretion with unchanged insulin sensitivity. These differences remained significant after excluding diabetics and the IFG/IGT group from the analysis. No associations of the genotype with the shape of OGTT-based trajectories, with glucagon or with chronobiological patterns were observed. However, the shape of the trajectories differed significantly between men and women. ConclusionIn a representative sample of the Czech population, the G allele of the rs10830963 polymorphism is associated with impaired early phase of beta cell function, and this is evident even in healthy individuals.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/NU20-01-00308" target="_blank" >NU20-01-00308: Longitudinal monitoring of glucose tolerance dynamics-risk and protective factors</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

FRONTIERS IN ENDOCRINOLOGY

ISSN

1664-2392

e-ISSN

—

Volume of the periodical

13

Issue of the periodical within the volume

June

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

Article Number 868364

UT code for WoS article

000813181100001

EID of the result in the Scopus database

2-s2.0-85133381372