Maternal negative affect in pregnancy predicts cytokine levels which in turn predict birth outcomes - A prospective longitudinal study in a low-risk population

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023761%3A_____%2F24%3AN0000047" target="_blank" >RIV/00023761:_____/24:N0000047 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/24:10483815 RIV/00216208:11210/24:10483815

Result on the web

<a href="https://doi.org/10.1016/j.jad.2024.08.141" target="_blank" >https://doi.org/10.1016/j.jad.2024.08.141</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jad.2024.08.141" target="_blank" >10.1016/j.jad.2024.08.141</a>

Result language

angličtina

Original language name

Maternal negative affect in pregnancy predicts cytokine levels which in turn predict birth outcomes - A prospective longitudinal study in a low-risk population

Original language description

Background: Stress and negative mood in pregnancy have been linked to less favorable birth outcomes, but the mechanisms underlying this effect remain largely unknown. We examined associations between emotions in pregnancy, pro- and anti-inflammatory cytokines (IFN-gamma, IL-6, IL-8, IL-10, IL-12, IL-17, MCP-1, MIP-1R, TNF-alpha) and birth outcomes (gestational age at birth and birth weight) in a low-risk sample. Methods: At each trimester of pregnancy, participants (N = 74) completed the Positive and Negative Affect Schedule, Perceived Stress Scale, Edinburgh Postnatal Depression Scale, and State-Trait Anxiety Inventory. They provided blood samples in the third trimester. Multivariate regression with a reduction of dimensionality (orthogonal projection to latent structures) was used to assess associations between maternal emotions, cytokine levels, and birth outcomes. Results: We found significant positive associations between negative mood (depressive symptoms in the second and third trimesters and negative affect in the third trimester) and anti-inflammatory cytokine IL-10 levels, and negative associations between maternal distress in the second and third trimesters and pro-/anti-inflammatory cytokine ratios (IFN-gamma/IL-10, TNF-alpha/IL-10 and IL-6/IL-10). Higher levels of pro-inflammatory cytokines IFN-gamma, IL12, IL-17, and TNF-alpha were associated with younger gestational age at birth and lower birth weight. Limitations: We did not control for relevant factors such as social support, health-related behaviors, or cortisol levels. Conclusions: Negative mood in mid- and late pregnancy may shift cytokine balance toward the anti-inflammatory cytokine dominance. Our results provide further evidence for the negative association between pro-inflammatory cytokines in late pregnancy and gestational age at birth/birth weight, which we observed even in a low-risk population.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30215 - Psychiatry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Affective Disorders

ISSN

0165-0327

e-ISSN

1573-2517

Volume of the periodical

366

Issue of the periodical within the volume

December

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

9

Pages from-to

345-353

UT code for WoS article

001312869300001

EID of the result in the Scopus database

2-s2.0-85202859838