MxA mRNA decrease preceding NAb detection in IFNβ-treated MS patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F12%3A00007376" target="_blank" >RIV/00023884:_____/12:00007376 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/brb3.644" target="_blank" >http://dx.doi.org/10.1002/brb3.644</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/brb3.644" target="_blank" >10.1002/brb3.644</a>
Alternative languages
Result language
angličtina
Original language name
MxA mRNA decrease preceding NAb detection in IFNβ-treated MS patients
Original language description
Background Multiple sclerosis (MS) patients treated with interferon beta (IFNβ) are at risk of a declining response to treatment because of the production of IFNβ‐neutralizing antibodies (NAbs). The expression of Myxovirus resistance protein A (MxA) mRNA is regarded as a marker of IFNβ bioactivity. Aims The aim of this study was to analyze the kinetics of MxA mRNA expression during long‐term IFNβ treatment and assess its relationship to NAb production. Methods A prospective, observational, open‐label, non‐randomized study was designed in multiple sclerosis patients starting IFNβ treatment. NAbs and MxA mRNA were monitored every six months. Results 119 patients were consecutively enrolled and 107 were included in the final analysis. Both the presence of NAbs and a decrease in MxA mRNA below the cut off were revealed in 15 patients, however, in six patients (40%) positivity for NAbs was preceded by the decrease in MxA mRNA. In addition, a further six patients showing a decline in MxA mRNA did not have detectable NAbs. Conclusion Our data indicate that quantification of MxA mRNA is a more sensitive identifier of loss of IFNβ efficacy than the NAb positivity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Brain and Behavior
ISSN
2162-3279
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
February
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
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UT code for WoS article
000397564200015
EID of the result in the Scopus database
2-s2.0-85012889381