MxA mRNA decrease preceding NAb detection in IFN beta-treated MS patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10360642" target="_blank" >RIV/00216208:11110/17:10360642 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/17:10360642 RIV/00064203:_____/17:10360642 RIV/00064165:_____/17:10360642
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/brb3.644/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/brb3.644/abstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/brb3.644" target="_blank" >10.1002/brb3.644</a>

Result language
angličtina
Original language name
MxA mRNA decrease preceding NAb detection in IFN beta-treated MS patients
Original language description
Background: Multiple sclerosis (MS) patients treated with interferon beta (IFN) are at risk of a declining response to treatment because of the production of IFN-neutralizing antibodies (NAbs). The expression of Myxovirus resistance protein A (MxA) mRNA is regarded as a marker of IFN bioactivity. Aims: The aim of this study was to analyze the kinetics of MxA mRNA expression during long-term IFN treatment and assess its relationship to NAb production. Methods: A prospective, observational, open-label, non-randomized study was designed in multiple sclerosis patients starting IFN treatment. NAbs and MxA mRNA were monitored every six months. Results: 119 patients were consecutively enrolled and 107 were included in the final analysis. Both the presence of NAbs and a decrease in MxA mRNA below the cut off were revealed in 15 patients, however, in six patients (40%) positivity for NAbs was preceded by the decrease in MxA mRNA. In addition, a further six patients showing a decline in MxA mRNA did not have detectable NAbs. Conclusion: Our data indicate that quantification of MxA mRNA is a more sensitive identifier of loss of IFN efficacy than the NAb positivity.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30103 - Neurosciences (including psychophysiology)

Project
<a href="/en/project/NT12385" target="_blank" >NT12385: Monitoring of MxA mRNA Expression as a Marker of Rresponse to Interferon ß Therapy in Patients with Multiple Sclerosis.</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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