Radiosurgery of brain cavernomas - long-term results

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F13%3A%230005344" target="_blank" >RIV/00023884:_____/13:#0005344 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Radiosurgery of brain cavernomas - long-term results
Original language description
The radiosurgery of cavernomas remains a controversial issue. The only way to verify the positive effect of the treatment is by clinical observation during a longer follow up period, where the decreased annual risk of rebleeding should be observed after the latent interval inherent to radiosurgery. Besides this, an improvement in clinical symptoms (e.g. secondary epilepsy) and regression of the treated lesion might also be observed. In a group of 112 patients with brain cavernomas treated in our centre between 1992 2000 with the marginal dose of median 16 Gy the risk of bleeding decreased from 2% before the treatment to 0,5% after 2 years latent interval (median follow up 84 months). A decrease of the cavernoma was observed in 53% of cases and an increase in 6.4%. Epilepsy, if present before the treatment, improved in 45% of cases. Risk of temporary and permanent morbidity caused by radiosurgery was 14.6% and 0.9% respectively. This morbidity can be reduced by a lower marginal dose and future studies should show if repeated radiosurgery decreases the risks from natural course of the disease in those cases where the initial radiosurgery failed.
Czech name
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Czech description
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Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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