Graft patency after FFR-guided versus angiography-guided coronary artery bypass grafting: the GRAFFITI trial

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F19%3A00008546" target="_blank" >RIV/00023884:_____/19:00008546 - isvavai.cz</a>

Result on the web

<a href="https://europepmc.org/article/med/31270037" target="_blank" >https://europepmc.org/article/med/31270037</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4244/EIJ-D-19-00463" target="_blank" >10.4244/EIJ-D-19-00463</a>

Result language

angličtina

Original language name

Graft patency after FFR-guided versus angiography-guided coronary artery bypass grafting: the GRAFFITI trial

Original language description

Aims: The aim of this study was to assess prospectively the clinical benefits of fractional flow reserve (FFR) in guiding coronary artery bypass grafting (CABG). Methods and results: GRAFFITI is a single-blinded, prospective, multicentre, randomised controlled trial of FFR-guided versus angiography-guided CABG. We enrolled patients undergoing coronary angiography, having a significantly diseased left anterior descending artery or left main stem and at least one more major coronary artery with intermediate stenosis, assessed by FFR. Surgical strategy was defined based on angiography, blinded to FFR values prior to randomisation. After randomisation, patients were operated on either following the angiography-based strategy (angiography-guided group) or according to FFR, i.e., with an FFR <= 0.80 as cut-off for grafting (FFR-guided group). The primary endpoint was graft patency at 12 months. Between March 2012 and December 2016, 172 patients were randomised either to the angiography-guided group (84 patients) or to the FFR-guided group (88 patients). The patients had a median of three [3; 4] lesions; diameter stenosis was 65% (50%; 80%), FFR was 0.72 (0.50; 0.82). Compared to the angiography-guided group, the FFR-guided group received fewer anastomoses (3 [3; 3] vs 2 [2; 3], respectively; p=0.004). One-year angiographic follow-up showed no difference in overall graft patency (126 [80%] vs 113 [81%], respectively; p=0.885). One-year clinical follow-up, available in 98% of patients, showed no difference in the composite of death, myocardial infarction, target vessel revascularisation and stroke.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

EuroIntervention

ISSN

1969-6213

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

11

Country of publishing house

FR - FRANCE

Number of pages

7

Pages from-to

999-1005

UT code for WoS article

000501563600013

EID of the result in the Scopus database

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