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Graft patency after FFR-guided versus angiography-guided coronary artery bypass grafting: the GRAFFITI trial

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F19%3A00072347" target="_blank" >RIV/65269705:_____/19:00072347 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/19:00112632

  • Result on the web

    <a href="https://eurointervention.pcronline.com/article/graft-patency-after-ffr-guided-versus-angiography-guided-coronary-artery-bypass-grafting-the-graffiti-trial" target="_blank" >https://eurointervention.pcronline.com/article/graft-patency-after-ffr-guided-versus-angiography-guided-coronary-artery-bypass-grafting-the-graffiti-trial</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.4244/EIJ-D-19-00463" target="_blank" >10.4244/EIJ-D-19-00463</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Graft patency after FFR-guided versus angiography-guided coronary artery bypass grafting: the GRAFFITI trial

  • Original language description

    Aims: The aim of this study was to assess prospectively the clinical benefits of fractional flow reserve (FFR) in guiding coronary artery bypass grafting (CABG). Methods and results: GRAFFITI is a single-blinded, prospective, multicentre, randomised controlled trial of FFR-guided versus angiography-guided CABG. We enrolled patients undergoing coronary angiography, having a significantly diseased left anterior descending artery or left main stem and at least one more major coronary artery with intermediate stenosis, assessed by FFR. Surgical strategy was defined based on angiography, blinded to FFR values prior to randomisation. After randomisation, patients were operated on either following the angiography-based strategy (angiography-guided group) or according to FFR, i.e., with an FFR &lt;= 0.80 as cut-off for grafting (FFR-guided group). The primary endpoint was graft patency at 12 months. Between March 2012 and December 2016, 172 patients were randomised either to the angiography-guided group (84 patients) or to the FFR-guided group (88 patients). The patients had a median of three [3; 4] lesions; diameter stenosis was 65% (50%; 80%), FFR was 0.72 (0.50; 0.82). Compared to the angiography-guided group, the FFR-guided group received fewer anastomoses (3 [3; 3] vs 2 [2; 3], respectively; p=0.004). One-year angiographic follow-up showed no difference in overall graft patency (126 [80%] vs 113 [81%], respectively; p=0.885). One-year clinical follow-up, available in 98% of patients, showed no difference in the composite of death, myocardial infarction, target vessel revascularisation and stroke. Conclusions: FFR guidance of CABG has no impact on one-year graft patency, but it is associated with a simplified surgical procedure. ClinicalTrials.gov Identifier: NCT01810224

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30201 - Cardiac and Cardiovascular systems

Result continuities

  • Project

  • Continuities

    N - Vyzkumna aktivita podporovana z neverejnych zdroju

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Eurointervention

  • ISSN

    1774-024X

  • e-ISSN

  • Volume of the periodical

    15

  • Issue of the periodical within the volume

    11

  • Country of publishing house

    FR - FRANCE

  • Number of pages

    10

  • Pages from-to

    "E999"-"+"

  • UT code for WoS article

    000501563600013

  • EID of the result in the Scopus database