Stereotactic radiosurgery for clinoid meningiomas: a multi-institutional study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F21%3A00008954" target="_blank" >RIV/00023884:_____/21:00008954 - isvavai.cz</a>
Result on the web
<a href="https://pubmed.ncbi.nlm.nih.gov/34427769/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/34427769/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00701-021-04972-3" target="_blank" >10.1007/s00701-021-04972-3</a>
Alternative languages
Result language
angličtina
Original language name
Stereotactic radiosurgery for clinoid meningiomas: a multi-institutional study
Original language description
Purpose Resection of clinoid meningiomas can be associated with significant morbidity. Experience with stereotactic radiosurgery (SRS) for clinoid meningiomas remains limited. We studied the safety and effectiveness of SRS for clinoid meningiomas. Methods From twelve institutions participating in the International Radiosurgery Research Foundation, we pooled patients treated with SRS for radiologically suspected or histologically confirmed WHO grade I clinoid meningiomas. Results Two hundred seven patients (median age: 56 years) underwent SRS for clinoid meningiomas. Median treatment volume was 8.02 cm(3), and 87% of tumors were immediately adjacent to the optic apparatus. The median tumor prescription dose was 12 Gy, and the median maximal dose to the anterior optic apparatus was 8.5 Gy. During a median post-SRS imaging follow-up of 51.1 months, 7% of patients experienced tumor progression. Greater margin SRS dose (HR = 0.700, p = 0.007) and pre-SRS radiotherapy (HR = 0.004, p < 0.001) were independent predictors of better tumor control. During median visual follow-up of 48 months, visual function declined in 8% of patients. Pre-SRS visual deficit (HR = 2.938, p = 0.048) and maximal radiation dose to the optic apparatus of >= 10 Gy (HR = 11.297, p = 0.02) independently predicted greater risk of post-SRS visual decline. Four patients experienced new post-SRS cranial nerve V neuropathy. Conclusions SRS allows durable control of clinoid meningiomas and visual preservation in the majority of patients. Greater radiosurgical prescription dose is associated with better tumor control. Radiation dose to the optic apparatus of >= 10 Gy and visual impairment before the SRS increase risk of visual deterioration.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Neurochirurgica
ISSN
0001-6268
e-ISSN
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Volume of the periodical
163
Issue of the periodical within the volume
10
Country of publishing house
AT - AUSTRIA
Number of pages
9
Pages from-to
2861-2869
UT code for WoS article
000687911900001
EID of the result in the Scopus database
2-s2.0-85113302595