Stereotactic radiosurgery for treatment of radiation-induced meningiomas: A multiinstitutional study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F21%3A00009105" target="_blank" >RIV/00023884:_____/21:00009105 - isvavai.cz</a>
Result on the web
<a href="https://thejns.org/view/journals/j-neurosurg/135/3/article-p862.xml" target="_blank" >https://thejns.org/view/journals/j-neurosurg/135/3/article-p862.xml</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3171/2020.7.JNS202064" target="_blank" >10.3171/2020.7.JNS202064</a>
Alternative languages
Result language
angličtina
Original language name
Stereotactic radiosurgery for treatment of radiation-induced meningiomas: A multiinstitutional study
Original language description
OBJECTIVE Radiation-induced meningiomas (RIMs) are associated with aggressive clinical behavior. Stereotactic radiosurgery (SRS) is sometimes considered for selected RIMs. The authors investigated the effectiveness and safety of SRS for the management of RIMs. METHODS From 12 institutions participating in the International Radiosurgery Research Foundation, the authors pooled patients who had prior cranial irradiation and were subsequently clinically diagnosed with WHO grade I meningiomas that were managed with SRS. RESULTS Fifty-two patients underwent 60 SRS procedures for histologically confirmed or radiologically suspected WHO grade I RIMs. The median ages at initial cranial radiation therapy and SRS for RIM were 5.5 years and 39 years, respectively. The most common reasons for cranial radiation therapy were leukemia (21%) and medulloblastoma (17%). There were 39 multiple RIMs (35%), the mean target volume was 8.61 +/- 7.80 cm(3), and the median prescription dose was 14 Gy. The median imaging follow-up duration was 48 months (range 4-195 months). RIM progressed in 9 patients (17%) at a median duration of 30 months (range 3-45 months) after SRS. Progression-free survival at 5 years post-SRS was 83%. Treatment volume >= 5 cm(3) predicted progression (HR 8.226, 95% CI 1.028- 65.857, p = 0.047). Seven patients (14%) developed new neurological symptoms or experienced SRS- related complications or T2 signal change from 1 to 72 months after SRS. CONCLUSIONS SRS is associated with durable local control of RIMs in the majority of patients and has an acceptable safety profile. SRS can be considered for patients and tumors that are deemed suboptimal, poor surgical candidates, and those whose tumor again progresses after removal.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
—
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neurosurgery
ISSN
0022-3085
e-ISSN
—
Volume of the periodical
135
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
862-870
UT code for WoS article
000692539600005
EID of the result in the Scopus database
2-s2.0-85113295304