All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Stereotactic radiosurgery for treatment of radiation-induced meningiomas: A multiinstitutional study

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F21%3A00009105" target="_blank" >RIV/00023884:_____/21:00009105 - isvavai.cz</a>

  • Result on the web

    <a href="https://thejns.org/view/journals/j-neurosurg/135/3/article-p862.xml" target="_blank" >https://thejns.org/view/journals/j-neurosurg/135/3/article-p862.xml</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3171/2020.7.JNS202064" target="_blank" >10.3171/2020.7.JNS202064</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Stereotactic radiosurgery for treatment of radiation-induced meningiomas: A multiinstitutional study

  • Original language description

    OBJECTIVE Radiation-induced meningiomas (RIMs) are associated with aggressive clinical behavior. Stereotactic radiosurgery (SRS) is sometimes considered for selected RIMs. The authors investigated the effectiveness and safety of SRS for the management of RIMs. METHODS From 12 institutions participating in the International Radiosurgery Research Foundation, the authors pooled patients who had prior cranial irradiation and were subsequently clinically diagnosed with WHO grade I meningiomas that were managed with SRS. RESULTS Fifty-two patients underwent 60 SRS procedures for histologically confirmed or radiologically suspected WHO grade I RIMs. The median ages at initial cranial radiation therapy and SRS for RIM were 5.5 years and 39 years, respectively. The most common reasons for cranial radiation therapy were leukemia (21%) and medulloblastoma (17%). There were 39 multiple RIMs (35%), the mean target volume was 8.61 +/- 7.80 cm(3), and the median prescription dose was 14 Gy. The median imaging follow-up duration was 48 months (range 4-195 months). RIM progressed in 9 patients (17%) at a median duration of 30 months (range 3-45 months) after SRS. Progression-free survival at 5 years post-SRS was 83%. Treatment volume >= 5 cm(3) predicted progression (HR 8.226, 95% CI 1.028- 65.857, p = 0.047). Seven patients (14%) developed new neurological symptoms or experienced SRS- related complications or T2 signal change from 1 to 72 months after SRS. CONCLUSIONS SRS is associated with durable local control of RIMs in the majority of patients and has an acceptable safety profile. SRS can be considered for patients and tumors that are deemed suboptimal, poor surgical candidates, and those whose tumor again progresses after removal.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30103 - Neurosciences (including psychophysiology)

Result continuities

  • Project

  • Continuities

    N - Vyzkumna aktivita podporovana z neverejnych zdroju

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Neurosurgery

  • ISSN

    0022-3085

  • e-ISSN

  • Volume of the periodical

    135

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    9

  • Pages from-to

    862-870

  • UT code for WoS article

    000692539600005

  • EID of the result in the Scopus database

    2-s2.0-85113295304