The relationship between brain abnormalities and autistic psychopathology in pervasive developmental disorders

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F21%3A00009136" target="_blank" >RIV/00023884:_____/21:00009136 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/21:10427996 RIV/00064203:_____/21:10427996 RIV/00216208:11130/21:10427996 RIV/00216224:14210/21:00122010

Result on the web

<a href="https://jab.zsf.jcu.cz/artkey/jab-202102-0002_the-relationship-between-brain-abnormalities-and-autistic-psychopathology-in-pervasive-developmental-disorders.php" target="_blank" >https://jab.zsf.jcu.cz/artkey/jab-202102-0002_the-relationship-between-brain-abnormalities-and-autistic-psychopathology-in-pervasive-developmental-disorders.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.32725/jab.2021.009" target="_blank" >10.32725/jab.2021.009</a>

Result language

angličtina

Original language name

The relationship between brain abnormalities and autistic psychopathology in pervasive developmental disorders

Original language description

The aim of the present research has been to determine whether there is a relationship between brain abnormalities found on magnetic resonance imaging (MRI) and autistic psychopathology. A retrospective analysis covering a period between 1998 and 2015 induded 489 children with autism (404 boys, 85 girls; average age 8.0 +/- 4.2 years) who underwent an MRI of the brain. For dinical diagnosis of autism, the International Classification of Diseases, 10th revision (ICD-10), was used. Autistic psychopathology was evaluated by means of the Autism Diagnostic Interview - Revised. The Spearman nonparametric correlation analysis and chi-square test were used to examine the possible relationships between variables. The group of autistic children did not manifest a statistically significant correlation between the parameters examined on MRI and autistic psychopathology. A correlation between other cysts and repetitive behavior was significant only at trend level (P = 0.054). Gliosis of the brain was significantly more frequent in autistic children with mental retardation than in children without mental retardation (14.1% vs. 7.4%; P = 0.028). Nonmyelinated areas in the brain were significantly more frequent in autistic children with autistic regression than in children without autistic regression (29.9% vs. 15.7%; P = 0.008). Mental retardation was significantly more frequent in autistic children with autistic regression than in children without regression (73.2% vs. 52.5%; P = 0.002). Our research study did not reveal a statistically significant correlation of brain abnormalities on MRI with autistic psychopathology.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

<a href="/en/project/NV18-04-00085" target="_blank" >NV18-04-00085: The role of maternal autoantibodies in pathogenesis of autism spectrum disorders</a><br>

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal Of Applied Biomedicine

ISSN

1214-021X

e-ISSN

—

Volume of the periodical

19

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

91-96

UT code for WoS article

000649173600002

EID of the result in the Scopus database

2-s2.0-85107001799