The yield of structural magnetic resonance imaging in autism spectrum disorders
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F19%3A10403035" target="_blank" >RIV/00064203:_____/19:10403035 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/19:10403035
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=_Oy6DepYb5" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=_Oy6DepYb5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2018.074" target="_blank" >10.5507/bp.2018.074</a>
Alternative languages
Result language
angličtina
Original language name
The yield of structural magnetic resonance imaging in autism spectrum disorders
Original language description
Aims. The aim of our study was to assess the yield of routine brain magnetic resonance imaging (MRI) performed at our hospital as part of the diagnostic procedures focused on autism. Methods. Our retrospective study involved children who had attended a diagnostic examination focused on autism and underwent brain MRIs between 1998-2015. The International Classification of Diseases, 10th edition was used to make clinical diagnoses. In 489 children (404 boys, 85 girls; mean age 8.0+-4.2 years), a diagnosis of a pervasive developmental disorder was confirmed. Forty-five children, where the autism diagnosis was ruled out (but other psychiatric diagnoses found), served as a control group (36 boys, 9 girls; mean age 7.0+-2.4 years). We can assume that in such a control group, brain abnormalities might occur at a higher frequency than in truly healthy children which would have the effect of reducing the difference between the groups. Results. MRI pathologies were more common in the autistic (45.4%) compared to the control group (31.8%) but the difference was significant only at the trend level (P=0.085). Hypoplasia of the corpus callosum (CC) was significantly more common in the autistic vs. the control group (13.7 vs. 0%; P=0.009). In contrast, nonmyelinated areas of white matter were significantly more common in controls (31.8 vs.17.3%; P=0.018). Differences in other parameters were not significant. Conclusion. The occurrence of CC hypoplasia on routine MRI scans could represent a "red flag" for suspicion of autism. (C) 2019 The Authors.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
<a href="/en/project/NV16-31754A" target="_blank" >NV16-31754A: Neuroanatomical substrate of social and language impairments: neuroimaging and psychopathology in neurodevelopmental disorders</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical Papers
ISSN
1213-8118
e-ISSN
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Volume of the periodical
163
Issue of the periodical within the volume
4
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
5
Pages from-to
374-378
UT code for WoS article
000506054400014
EID of the result in the Scopus database
2-s2.0-85076594975