Increasing prevalence of hypertension during long-term follow-up in children with autosomal dominant polycystic kidney disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F21%3A00009219" target="_blank" >RIV/00023884:_____/21:00009219 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/21:10427721 RIV/00216208:11130/21:10427721

Result on the web

<a href="https://link.springer.com/article/10.1007/s00467-021-05104-w" target="_blank" >https://link.springer.com/article/10.1007/s00467-021-05104-w</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00467-021-05104-w" target="_blank" >10.1007/s00467-021-05104-w</a>

Result language

angličtina

Original language name

Increasing prevalence of hypertension during long-term follow-up in children with autosomal dominant polycystic kidney disease

Original language description

Introduction Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. Kidney cysts form over the course of the disease and kidney function slowly declines, usually leading to kidney failure in middle to late adulthood. However, some symptoms, such as hypertension or proteinuria, can be present at an earlier age. In this study, we aimed to quantify early complications in children over time. Methods All 69 children with ADPKD from our pediatric nephrology center who met inclusion criteria (follow-up >= 1 year and >= 2 recorded visits) were studied. Analysis of changes in kidney size, cyst count, estimated glomerular filtration rate (eGFR), urinary protein excretion, and blood pressure was performed. Results The median time of follow-up was 6.3 years (range 8.4-14.8). Over the follow-up, kidneys grew from 109 to 115% of expected length (p < 0.0001), number of cysts increased at a rate of 0.8 cyst/kidney/year, and the prevalence of hypertension increased significantly from 20 to 38% (p < 0.015). The eGFR and absolute urinary protein excretion remained stable. Conclusions This study shows that children with ADPKD suffer from increasing prevalence of hypertension during the course of the disease parallel to the increasing number of kidney cysts and size despite normal and stable kidney function and proteinuria.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30209 - Paediatrics

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pediatric Nephrology

ISSN

0931-041X

e-ISSN

—

Volume of the periodical

36

Issue of the periodical within the volume

11

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

3717-3723

UT code for WoS article

000651676600002

EID of the result in the Scopus database

2-s2.0-85106334239