Proteinuria in children with autosomal dominant polycystic kidney disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10387160" target="_blank" >RIV/00216208:11130/18:10387160 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/18:10387160
Result on the web
<a href="https://doi.org/10.23736/S0026-4946.16.04404-2" target="_blank" >https://doi.org/10.23736/S0026-4946.16.04404-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.23736/S0026-4946.16.04404-2" target="_blank" >10.23736/S0026-4946.16.04404-2</a>
Alternative languages
Result language
angličtina
Original language name
Proteinuria in children with autosomal dominant polycystic kidney disease
Original language description
BACKGROUND: Proteinuria is a common complication in adults with autosomal dominant polycystic kidney disease (ADPKD) and serves as a risk factor for progression. However, proteinuria has rarely been examined in children with ADPKD and the type of proteinuria has not yet been investigated. The aim of the study was to assess the prevalence and to analyse the types of proteinuria in children with ADPKD. METHODS: Children with ADPKD followed-up in our tertiary centres during the years 2012-2013 were investigated in a cross-sectional study. Morning urine was tested for total protein (PROT), albumin (ALB) and alpha-1-microglobulin (AMG). Renal function was assessed from serum creatinine as estimated glomerular filtration rate. RESULTS: Thirty-seven children of median age 11.2 (2.0-18.0) years were investigated. Median (range) PROT, ALB and AMG (in mg/mmol creatinine) were 15.1 (6.2-64.8), 2.54 (0.54-37.25) and 3.22 (0.04-10.16), respectively. Pathological total proteinuria (> 22) was found in 30% of children, albuminuria (> 2.2) in 49% of children and alpha-1-microglobulinuria (> 0.55) in 65% of children. No correlation was found between PROT, ALB or AMG and office blood pressure, kidney size or estimated glomerular filtration rate. CONCLUSIONS: Proteinuria in children with ADPKD is a frequent finding, the most common type is tubular proteinuria. It should be measured in all ADPKD children.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30209 - Paediatrics
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Minerva Pediatrica
ISSN
0026-4946
e-ISSN
—
Volume of the periodical
70
Issue of the periodical within the volume
5
Country of publishing house
IT - ITALY
Number of pages
5
Pages from-to
413-417
UT code for WoS article
000452522400001
EID of the result in the Scopus database
2-s2.0-85054776612