Translational Rabbit Model of Chronic Cardiac Pacing

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F23%3A00009518" target="_blank" >RIV/00023884:_____/23:00009518 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/23:10453987 RIV/00064203:_____/23:10453987

Result on the web

<a href="https://www.jove.com/t/64512/translational-rabbit-model-of-chronic-cardiac-pacing" target="_blank" >https://www.jove.com/t/64512/translational-rabbit-model-of-chronic-cardiac-pacing</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3791/64512" target="_blank" >10.3791/64512</a>

Result language

angličtina

Original language name

Translational Rabbit Model of Chronic Cardiac Pacing

Original language description

Animal models of cardiac pacing are beneficial for testing novel devices, studying the pathophysiology of artificially paced heart rhythms, and studying arrhythmia-induced cardiomyopathies and subsequent heart failure. Currently, only a few such models are available, and they mostly require extensive resources. We report a new experimental cardiac pacing model in small mammals with the potential to study arrhythmia-induced heart failure. In six New Zealand white rabbits (mean weight: 3.5 kg) under general inhalational anesthesia the jugular region was dissected and a single pacing lead was inserted via the right external jugular vein. Using fluoroscopic guidance, the lead was further advanced to the right ventricular apex, where it was stabilized using passive fixation. A cardiac pacemaker was then connected and buried in a subcutaneous pocket. The pacemaker implantation was successful with good healing; the rabbit anatomy is favorable for the lead placement. During 6 months of follow-up with intermittent pacing, the mean sensed myocardial potential was 6.3 mV (min: 2.8 mV, max: 12 mV), and the mean lead impedance measured was 744 omega (min: 370 omega, max: 1014 omega). The pacing threshold was initially 0.8 V +/- 0.2 V and stayed stable during the follow-up. This present study is the first to present successful transvenous cardiac pacing in a small-mammal model. Despite the size and tissue fragility, human-size instrumentation with adjustments can safely be used for chronic cardiac pacing, and thus, this innovative model is suitable for studying the development of arrhythmia -induced cardiomyopathy and consequent heart failure pathophysiology.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Visualized Experiments

ISSN

1940-087X

e-ISSN

—

Volume of the periodical

191

Issue of the periodical within the volume

January

Country of publishing house

IL - THE STATE OF ISRAEL

Number of pages

16

Pages from-to

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UT code for WoS article

000926828500013

EID of the result in the Scopus database

2-s2.0-85146331544