Ultrasound-Navigated Multiple Hippocampal Transections: An Anatomical Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F24%3A00009902" target="_blank" >RIV/00023884:_____/24:00009902 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/24:10474241 RIV/00216208:11150/24:10474241 RIV/00064203:_____/24:10474241
Result on the web
<a href="https://thieme-connect.de/products/ejournals/abstract/10.1055/s-0043-1771276" target="_blank" >https://thieme-connect.de/products/ejournals/abstract/10.1055/s-0043-1771276</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1055/s-0043-1771276" target="_blank" >10.1055/s-0043-1771276</a>
Alternative languages
Result language
angličtina
Original language name
Ultrasound-Navigated Multiple Hippocampal Transections: An Anatomical Study
Original language description
Background Multiple hippocampal transection (MHT) is a surgical technique used for the treatment of drug-resistant mesial temporal lobe epilepsy in situations where standard procedures would pose a high risk for memory deterioration. During MHT, the longitudinal fibers of the hippocampus, implicated in epilepsy spreading, are interrupted, while the transverse memory circuits are spared. The extent of MHT is governed by intraoperative electrocorticography; abolition of epileptic discharges serves as an end point to terminate the transection. In other words, the aim of MHT is not the anatomical completeness of hippocampal transection. In contrast, we hypothesize that only the complete transection of hippocampal cross-section is needed to durably terminate epilepsy, avoiding possible postoperative reorganization of longitudinal pathways. Here, we report an anatomical study designed to evaluate the feasibility of complete transection of hippocampus with the aid of ultrasound neuronavigation and we propose new instruments to reach this goal.Methods Five cadaveric brains were analyzed in this study. MHT was performed on both sides of each brain either with or without ultrasound neuronavigation. The percentage of transected cross-section of the hippocampus was measured using magnetic resonance imaging (MRI) and both sides were compared.Results The ultrasound-guided MHTs were more likely to achieve complete hippocampal transection compared with the nonnavigated MHT transection (73 vs 58%; p < 0.01). Our study also allowed us to propose specialized transectors to minimize invasivity of this procedure.Conclusion Completeness of MHT can be better reached with the aid of an ultrasound neuronavigation system; modified instruments for this procedure were also designed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
—
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neurological Surgery Part A-Central European Neurosurgery
ISSN
2193-6315
e-ISSN
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Volume of the periodical
85
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
444-450
UT code for WoS article
001147728600001
EID of the result in the Scopus database
2-s2.0-85184199055