Hippocampal volume in first-episode schizophrenia and longitudinal course of the illness
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F16%3A00065610" target="_blank" >RIV/65269705:_____/16:00065610 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/16:00091001
Result on the web
<a href="http://dx.doi.org/10.1080/15622975.2016.1199893" target="_blank" >http://dx.doi.org/10.1080/15622975.2016.1199893</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/15622975.2016.1199893" target="_blank" >10.1080/15622975.2016.1199893</a>
Alternative languages
Result language
angličtina
Original language name
Hippocampal volume in first-episode schizophrenia and longitudinal course of the illness
Original language description
Objectives: Several lines of evidence suggest an adverse effect of psychotic episodes on brain morphology. It is not clear if this relationship reflects the cumulative effect of psychotic outbursts on the gradual progressive reduction of hippocampal tissue or an increased tendency toward psychotic episodes in patients with a smaller hippocampus at the beginning of the illness.Methods: This is a longitudinal 4-year prospective study of patients with first-episode schizophrenia (FES, N=58). Baseline brain anatomical scans (at FES) were analysed using voxel-based morphometry and atlas-based volumetry of the hippocampal subfields. The effects of first-episode duration on the hippocampal morphology, and the effect of baseline hippocampal morphology on illness course with relapses, number of psychotic episodes and residual symptoms were analysed.Results: A significant negative correlation was detected between first-episode duration and baseline hippocampal morphology. Relapse, number of psychotic episodes and residual symptoms had no correlation with baseline hippocampal volume.Conclusions: We replicated the effect of psychosis duration on hippocampal volume already at the time first-episode, which supports the concept of toxicity of psychosis. The indices of a later unfavourable course of schizophrenia had no correlation with baseline brain morphology, suggesting that there is no baseline morphological abnormality of the hippocampus that predisposes the patient to frequent psychotic outbursts.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FL - Psychiatry, sexology
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
World journal of biological psychiatry
ISSN
1562-2975
e-ISSN
—
Volume of the periodical
17
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
429-438
UT code for WoS article
000383408000003
EID of the result in the Scopus database
—