Comparative study evaluating a new dose optimization software for Gamma Knife treatment planning – comparison of 80 challenging treatment plans
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F25%3A00010071" target="_blank" >RIV/00023884:_____/25:00010071 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21340/25:00388769
Result on the web
<a href="https://karger.com/sfn/article-abstract/doi/10.1159/000546214/927815/Comparative-study-evaluating-a-new-dose?redirectedFrom=fulltext" target="_blank" >https://karger.com/sfn/article-abstract/doi/10.1159/000546214/927815/Comparative-study-evaluating-a-new-dose?redirectedFrom=fulltext</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1159/000546214" target="_blank" >10.1159/000546214</a>
Alternative languages
Result language
angličtina
Original language name
Comparative study evaluating a new dose optimization software for Gamma Knife treatment planning – comparison of 80 challenging treatment plans
Original language description
Introduction In 2020, Elekta Instrument AB, Stockholm, released a new dose optimizer for Leksell GammaPlan, which includes the possibility of inverse planning. This study aimed to compare the new software with the previous manual version of treatment planning for stereotactic neurosurgery and evaluate its performance. Materials and Methods Four types of diagnoses — vestibular schwannomas, pituitary adenomas, meningiomas, and single brain metastasis — along with 80 clinically approved challenging cases, were selected for testing the new software. Key parameters, including coverage, selectivity, target volume, and doses to critical structures, were collected and statistically analyzed using a t-test. These parameters were compared based on the Leksell Gamma Knife Society standardization document for stereotactic radiosurgery, both for each diagnosis and for the entire dataset. Results The new software showed a clear advantage, particularly in sparing critical structures while maintaining or improving treatment plan conformity. Doses to critical structures such as the optic nerve, brainstem, cochlea, and pituitary gland decreased by an average of 13% (0.76 Gy), 7% (0.52 Gy), 7% (0.2 Gy), and 14% (1.04 Gy), respectively, reducing toxicity. Other plan parameters also showed significant improvements, except for the gradient index. Selectivity improved by 11% (0.03), the Shaw Conformity Index improved by 10% (0.1), and coverage improved by 0.01. Additionally, treatment time was reduced by 10% enhancing patient comfort. Conclusion Overall, Leksell Gamma Knife Lightning is faster and produces treatment plans with superior parameters compared to manual planning.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Stereotactic and Functional Neurosurgery
ISSN
1011-6125
e-ISSN
—
Volume of the periodical
103
Issue of the periodical within the volume
4
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
269-278
UT code for WoS article
001521942300001
EID of the result in the Scopus database
2-s2.0-105010246169