Concordance between amyloid PET and CSF biomarkers in clinical setting: a cross-platform comparison and in-depth analysis of discordant cases

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F25%3A00010168" target="_blank" >RIV/00023884:_____/25:00010168 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21460/25:00386430 RIV/00216208:11130/25:10505307 RIV/00064203:_____/25:10505307
Result on the web
<a href="https://www.nature.com/articles/s41598-025-23759-5?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20251114&utm_content=10.1038/s41598-025-23759-5" target="_blank" >https://www.nature.com/articles/s41598-025-23759-5?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20251114&utm_content=10.1038/s41598-025-23759-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-025-23759-5" target="_blank" >10.1038/s41598-025-23759-5</a>

Result language
angličtina
Original language name
Concordance between amyloid PET and CSF biomarkers in clinical setting: a cross-platform comparison and in-depth analysis of discordant cases
Original language description
Reliable detection of amyloid pathology is essential for Alzheimer’s disease (AD) diagnosis and treatment. We directly compared routine ELISA assays and the automated Lumipulse platform against quantitative amyloid PET in a real-world memory clinic cohort. In 153 participants, flutemetamol amyloid PET and CSF biomarkers were assessed across platforms. Concordance with PET and predictors of discordance were evaluated. PET visual reads and Centiloids showed near-perfect agreement (AUC = 0.99). The p-tau181/Aβ42 ratio achieved the highest concordance with PET (OPA 87% ELISA, 92% Lumipulse), while the Lumipulse Aβ42/40 ratio reached 93%. About 6% of participants showed consistent discordance between CSF and PET, associated with APOE ε4 and mixed or non-AD pathologies. Automated CSF assays align strongly with amyloid PET and support biomarker standardization. Persistent discrepancies between CSF and PET likely reflect underlying biological heterogeneity such as mixed or non-AD pathologies and APOE ε4 carriage.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging

Project
<a href="/en/project/LX22NPO5107" target="_blank" >LX22NPO5107: National institute for Neurological Research</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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