Glymphatic dysfunction evidenced by DTI-ALPS is related to obstructive sleep apnea intensity in newly diagnosed Parkinson's disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F25%3A00010174" target="_blank" >RIV/00023884:_____/25:00010174 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21460/25:00384006 RIV/00216208:11110/25:10499944 RIV/00064165:_____/25:10499944
Result on the web
<a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC12159171/" target="_blank" >https://pmc.ncbi.nlm.nih.gov/articles/PMC12159171/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41531-025-01018-8" target="_blank" >10.1038/s41531-025-01018-8</a>
Alternative languages
Result language
angličtina
Original language name
Glymphatic dysfunction evidenced by DTI-ALPS is related to obstructive sleep apnea intensity in newly diagnosed Parkinson's disease
Original language description
Glymphatic dysfunction potentially contributes to Parkinson's disease (PD) via impaired clearance of metabolic waste products. Obstructive sleep apnea (OSA) can disturb sleep, which is necessary for proper glymphatic function, and is frequent in PD. We investigated the glymphatic function in de novo PD and its relation to OSA. Fifty-four PD patients (mean age 58.9 +/- 12.2 years) and 32 controls (mean age 59.4 +/- 8.3 years) underwent polysomnography and 3 T magnetic resonance imaging of the brain. Diffusion tensor imaging along the perivascular space (DTI-ALPS) was calculated using atlas-based automatic regions of interest selection. In PD, ALPS-index negatively correlated with apnea-hypopnea index (rho = -0.41; p = 0.002), oxygen desaturation index (rho = -0.38; p = 0.006), sleep stage N1 (rho = -0.42; p = 0.002), and arousal index (rho = -0.24; p = 0.018), while in controls, no such correlations were observed. Glymphatic dysfunction is related to OSA severity in de novo PD but not
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
npj Parkinsons Disease
ISSN
2373-8057
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
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UT code for WoS article
001507452500001
EID of the result in the Scopus database
2-s2.0-105007823183