Local control and patient survival after stereotactic radiosurgery for esophageal cancer brain metastases: an international multicenter analysis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F25%3A00010213" target="_blank" >RIV/00023884:_____/25:00010213 - isvavai.cz</a>

Result on the web

<a href="https://thejns.org/view/journals/j-neurosurg/142/5/article-p1357.xml" target="_blank" >https://thejns.org/view/journals/j-neurosurg/142/5/article-p1357.xml</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3171/2024.7.JNS24920" target="_blank" >10.3171/2024.7.JNS24920</a>

Result language

angličtina

Original language name

Local control and patient survival after stereotactic radiosurgery for esophageal cancer brain metastases: an international multicenter analysis

Original language description

This study aimed to evaluate local control (LC) of tumors, patient overall survival (OS), and the safety of METHODS This retrospective cohort study used data from 15 International Radiosurgery Research Foundation facilities encompassing 67 patients with 185 EBMs managed using SRS between January 2000 and May 2022. The median patient age was 63 years, with a male predominance (92.5%). Most patients (64.2%) had a single brain metastasis, while 7.5% had more than 5 metastases. The median tumor volume was 0.9 cm3, and the median margin dose delivered to the tumor was 20 Gy. RESULTS The median OS post-SRS was 15.2 months, with 1-and 2-year OS rates of 65.7% and 32.3%, respectively. A significant inverse correlation was found between the number of EBMs and OS in the univariable analysis. LC rates at 1 and 2 years were 89% and 76%, respectively. Adverse radiation effects (AREs) were observed in 17.9% of patients, with 13.4% being mild and transient and 4.5% severely symptomatic (Common Terminology Criteria for Adverse Events grade 3). New intracranial disease developed in 58.2% of patients, with 1-and 2-year rates of 58% and 73%, respec-tively. CONCLUSIONS SRS for EBMs demonstrated high survival rates and effective tumor control, with a low incidence of severe AREs. These findings highlight the potential role of SRS in the multidisciplinary multimodality management para-digm of EBM.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neurosurgery

ISSN

0022-3085

e-ISSN

—

Volume of the periodical

142

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

1357-1365

UT code for WoS article

001488885700003

EID of the result in the Scopus database

2-s2.0-105004288442