Functional and Structural Similarity Between Insect and Human Hearts: Electrocardiography of Insect Hearts for Screening of New Cardioactive Drugs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027006%3A_____%2F13%3A00002818" target="_blank" >RIV/00027006:_____/13:00002818 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Functional and Structural Similarity Between Insect and Human Hearts: Electrocardiography of Insect Hearts for Screening of New Cardioactive Drugs
Original language description
The primordial formation of insect and human hearts is orchestrated by similar sets of genes. The rhythmicity of purely myogenic, peristaltic myocardial contractions of insect heart is determined by a posterior pacemaker nodus, which is analogous to sinoatrial or atrioventricular pacemaker nodi of the human heart. Insects are very mobile animals; there are vigorous neuromuscular contractions and extracardiac pulsations in haemocoelic pressure, which may seriously interfere with recordings of the heartbeat. This problem was solved by using larvae of the waxmoth, whose neuromuscular functions were totally paralysed by proteinaceous venom of the parasitic braconid wasp. The paralysed larvae survived motionless for 3 to 4 weeks, however, the regular myogenic pulsations of the heart and intestine, regulated by depolarisation potentials of the myocardial or intestinal cells, remained fully preserved. The paralysed larvae of the waxmoth are ideal object for cardiological research. By means of
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
<a href="/en/project/QJ1310057" target="_blank" >QJ1310057: Technology of controlled atmospheres and manipulated temperatures against pests of stored cereals.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Proceedings from Cardiotechnik 2013
ISBN
978-989-8565-78-5
ISSN
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e-ISSN
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Number of pages
8
Pages from-to
5-12
Publisher name
IOP Publishing Ltd
Place of publication
Bristol
Event location
Algarve, Portugal
Event date
Jan 1, 2013
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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