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Functional and Structural Similarity Between Insect and Human Hearts: Electrocardiography of Insect Hearts for Screening of New Cardioactive Drugs

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027006%3A_____%2F13%3A00002818" target="_blank" >RIV/00027006:_____/13:00002818 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Functional and Structural Similarity Between Insect and Human Hearts: Electrocardiography of Insect Hearts for Screening of New Cardioactive Drugs

  • Original language description

    The primordial formation of insect and human hearts is orchestrated by similar sets of genes. The rhythmicity of purely myogenic, peristaltic myocardial contractions of insect heart is determined by a posterior pacemaker nodus, which is analogous to sinoatrial or atrioventricular pacemaker nodi of the human heart. Insects are very mobile animals; there are vigorous neuromuscular contractions and extracardiac pulsations in haemocoelic pressure, which may seriously interfere with recordings of the heartbeat. This problem was solved by using larvae of the waxmoth, whose neuromuscular functions were totally paralysed by proteinaceous venom of the parasitic braconid wasp. The paralysed larvae survived motionless for 3 to 4 weeks, however, the regular myogenic pulsations of the heart and intestine, regulated by depolarisation potentials of the myocardial or intestinal cells, remained fully preserved. The paralysed larvae of the waxmoth are ideal object for cardiological research. By means of

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    FA - Cardiovascular diseases including cardio-surgery

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/QJ1310057" target="_blank" >QJ1310057: Technology of controlled atmospheres and manipulated temperatures against pests of stored cereals.</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Proceedings from Cardiotechnik 2013

  • ISBN

    978-989-8565-78-5

  • ISSN

  • e-ISSN

  • Number of pages

    8

  • Pages from-to

    5-12

  • Publisher name

    IOP Publishing Ltd

  • Place of publication

    Bristol

  • Event location

    Algarve, Portugal

  • Event date

    Jan 1, 2013

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article